四步调经法联合来曲唑对排卵障碍性不孕症的临床疗效研究  

Clinical Effect of Four-step Menstrual Regulation Combined with Letrozole on Patients with Ovulatory Disorder Infertility

作　　者：杜冰心 梁文珍[2] 徐云霞[2] 杨璇 汪翠萍 DU Bing-xin;LIANG Wen-zhen;XU Yun-xia;YANG Xuan;WANG Cui-ping(Department of Gynaecology,Anhui Hospital of Integrated Traditional Chinese and Western Medicine,Hefei 230031,China;Department of Gynecology and Obstetrics,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽省中西医结合医院妇科,安徽合肥230031 [2]安徽中医药大学第一附属医院妇产科,安徽合肥230031

出　　处：《现代中药研究与实践》2021年第5期67-71,共5页Research and Practice on Chinese Medicines

基　　金：安徽省高等学校自然科学重点项目研究基金(KJ2020A0446)。

摘　　要：目的探讨四步调经法对肾虚肝郁血瘀型排卵障碍性不孕症(ODI)的临床疗效。方法入组ODI患者,分别给予来曲唑治疗(对照组)和来曲唑联合四步调经法治疗(观察组)。比较两组患者治疗前、后中医证候积分、主卵泡直径、子宫内膜容受性指标及治疗后的总有效率和妊娠结局。结果治疗后观察组中医证候积分低于对照组(P<0.05),两组主卵泡直径比较差异无统计学意义(P>0.05);治疗后观察组的子宫内膜厚度、A型子宫内膜比例及Ⅲ型内膜下血流分布比例的增幅,以及子宫动脉阻力指数(RI)、搏动指数(PI)的降幅均大于对照组(P<0.05)。观察组的总有效率及妊娠率均高于对照组(P<0.05)。结论四步调经法联合来曲唑治疗ODI疗效确切,可能与其促进ODI患者卵泡发育及排卵,提高子宫内膜容受性有关。Objective To investigate clinical efficacy of four-step menstrual regulation method on ovulatory disorder infertility(ODI)caused by kidney deficiency,liver stagnation and blood stasis.Methods The eligible ODI patients of the control group is treated with letrozole,while the observation group is given four-step menstrual regulation combined with letrozole.Before and after the treatmenta,the TCM syndrome integral,main follicle diameter,endometrial receptivity index,the total effective rate and pregnancy outcom are compared between the two groups.Results After treatment,the TCM syndrome integral in the observation group are lower than those in the control group(P<0.05);there is no significant difference in the main follicle diameter between the two groups(P>0.05);the increase of endometrial thickness,the proportion of type A endometrium and the proportion of type Ⅲ subendometrial blood flow distribution,and the decrease of uterine artery resistance index(RI)and pulsatility index(PI)in the observation group are all greater than those in the control group(P<0.05).The overall response rate and pregnancy rate in the observation group are better than those of the control group(P<0.05).Conclusion The four-step menstrual regulation method combined with letrozole is effective in the treatment of ODI,which may be related to promoting follicular development and ovulation,and improving endometrial receptivity.

关 键 词：排卵障碍性不孕症 四步调经法 来曲唑 卵泡 子宫内膜容受性 

分 类 号：R285.6[医药卫生—中药学]