基于数据挖掘对中医药治疗无症状高尿酸血症的组方用药规律分析  

Analysis on Medication Rules of TCM Treatment for Asymptomatic Hyperuricemia Based on Data Mining

作　　者：徐朝辉 朱刚 刘传森 梁彪 李国毅 赵卿[1] Xu Zhaohui;Zhu Gang;Liu Chuansen;Liang Biao;Li Guoyi;Zhao Qing(Putuo hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062)

机构地区：[1]上海中医药大学附属普陀医院,上海200062

出　　处：《中药药理与临床》2021年第4期204-208,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：上海市中医医院第二届中医传承项目[编号:沪中医人(2020)2号];上海市普陀区卫生健康系统临床特色专病建设项目(编号:2019tszb02)。

摘　　要：目的:对中医药治疗无症状高尿酸血症组方用药规律进行分析,为临床用药及新药研发提供思路。方法:分别检索中国知网(CNKI)、万方、中文科技期刊全文数据库(VIP)及中国生物医学数据库(CBM)中关于中医药治疗无症状高尿酸血症的文献,运用中医传承辅助平台分析中医药治疗无症状高尿酸血症的组方用药规律。结果:通过平台分析发现涉及处方61首,中药125味;使用频次≥12次的药物有16味,排在前10位的药物分别为土茯苓、萆薢、薏苡仁、苍术、牛膝、车前子、白术、威灵仙、黄柏、泽泻;通过层次聚类分析得到核心组合12个,进一步演化得到新方组合6个。结论:中医药治疗无症状高尿酸血症的用药以健脾补肾、除湿化浊为根本治法,体现"标本兼顾"的治则及"未病先防,既病防变"的思想。Objective:We aimed to explore the medication rules of Chinese herbal prescription in the treatment of asymptomatic hyperuricemia based on the TCM Inheritance Support System(V2.50) software, and to provide references for clinical medication and new drugs development. Methods: CNKI, Wanfang, VIP and CBM databases were searched for literatures of TCM treatment for asymptomatic hyperuricemia, to explore the medication rules of TCM prescription by TCM Inheritance Support System(V2.50) platform. Results: 61 prescriptions and 125 Chinese herbs relevant with asymptomatic hyperuricemia were screened. 16 Herbs with use frequency higher than 12 times were found, in which the top 10 herbs were Tufuling(Smilax Glabra), Bixie(Dioscorea Septemloba Thunbt), Yiyiren(Coix Seed), Cangzhu(Rhizoma Atractylodis), Niuxi(Achyranthes Bidentata), Cheqianzi(Plantain Seed), Baizhu(Atractylodes Macrocephala), Weilingxian(Clematis Chinensis), Huangbo(Phellodendron Chinense), Zexie(Alisma Orientalis). Twelve core prescriptions were extracted by hierarchical clustering analysis, and 6 new prescriptions were further evolved. Conclusion: The treatment for asymptomatic hyperuricemia with TCM is based on Jianpibushen and Chushihuazhuo theory, reflecting the principle of Biaobenjiangu and the idea of Weibingxianfang and Jibingfangbian.

关 键 词：无症状高尿酸血症 数据挖掘 用药规律分析 血浊 

分 类 号：R259[医药卫生—中西医结合]