lncRNAs调控破骨细胞分化的研究进展  

Reasearch progress on the regulation of osteoclast differentiation by long noncoding RNAs

作　　者：朱琛煜 刘莉菲 邹军[1] 陈熙[2] ZHU Chen-Yu;LIU Li-Fei;ZOU Jun;CHEN Xi(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China;School of Sports Science,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]上海体育学院运动科学学院,上海200438 [2]温州医科大学体育科学学院,温州325035

出　　处：《生命科学》2021年第8期1002-1009,共8页Chinese Bulletin of Life Sciences

基　　金：温州市基础性科研项目(Y20190019);国家自然科学基金项目(81702235,81871835);上海市人类运动能力开发与保障重点实验室项目(上海体育学院)(11DZ2261100)。

摘　　要：长链非编码RNA(long noncoding RNAs,lncRNA)是一类长度大于200个核苷酸的非编码RNA,调控转录和转录后的基因表达,在各种生命活动过程中都起着重要的作用。破骨细胞是一种组织特异性的多核巨噬细胞,受多种信号因子和信号通路的调控,作为人体唯一的骨吸收细胞对维持骨代谢平衡具有非常重要的作用,当平衡被打破时则会引起一系列骨代谢疾病,如骨质疏松症、骨硬化症等。近些年研究发现,lncRNAs在破骨细胞分化过程中呈现差异化表达,且在其增殖、分化、凋亡过程中具有多重调控作用。该文就lncRNAs调控破骨细胞分化和功能的机制进行归纳总结,为破骨细胞功能异常所造成的骨代谢疾病提供新的研究靶点和诊疗思路。Long noncoding RNA(lncRNA)is a class of noncoding RNA that is longer than 200 nucleotides.It plays an important role in various activities of life by regulating transcriptional and post-transcriptional gene expression.The osteoclast is a tissue-specific macrophage polykaryon cell,which is regulated by various signal factors and signal pathways.As the only bone resorbing cell,it plays an important role in maintaining the balance of bone metabolism.Unbalance of this metabolism will cause bone-related diseases such as osteoporosis,osteopetrosis.Recently studies have revealed that lncRNAs differentially express during the differentiation of osteoclasts and have effects on the proliferation,differentiation,and apoptosis of osteoclasts.This article reviewed the mechanism of lncRNAs on regulating osteoclast differentiation and function to provide new research targets and diagnosis and treatment ideas for bone metabolism diseases caused by osteoclast dysfunction.

关 键 词：破骨细胞 破骨细胞分化 lncRNA 

分 类 号：Q522[生物学—生物化学] R336[医药卫生—人体生理学]