基于晶格玻尔兹曼方法的多段淋巴管模型  

Multi-segment lymphatic vessel model based on lattice Boltzmann method

作　　者：张乾毅 韦华健 李华兵[1] Zhang Qian-Yi;Wei Hua-Jian;Li Hua-Bing(School of Material Science and Engineering,Guilin University of Electronic Technology,Guilin 541004,China)

机构地区：[1]桂林电子科技大学材料科学与工程学院,桂林541004

出　　处：《物理学报》2021年第21期53-59,共7页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:11362005)资助的课题。

摘　　要：淋巴系统对人体的免疫及细胞的内环境稳态都有着重要的作用.与血液循环系统相似,淋巴系统也是遍布全身的管道系统,主要由淋巴液、淋巴管和淋巴器官构成.淋巴管的自发收缩驱动管内淋巴液的流动.淋巴管的自发收缩-舒张机制由Ca^(2+)和NO浓度的振荡反馈决定, NO在管内的分布对淋巴管的收缩循环起到重要作用.因淋巴液流动而作用在淋巴瓣膜上的剪切力是瓣膜产生NO的主要原因.在真实系统中,某段淋巴管中的NO分布会受到与其连接的淋巴管的影响,特别是上游的连接片段.通过晶格玻尔兹曼方法,建立了1个具有瓣膜结构的多段淋巴管模型,再现了淋巴管内Ca^(2+)和NO的反馈机制,瓣膜变化和淋巴液流动情况.该模型中存在3种淋巴管,分别是初始淋巴管、中间淋巴管和出口淋巴管.淋巴管的段数可以通过修改计算参数无限扩充.本文计算的段数为3—5段,每段淋巴管中有两对瓣膜.通过模型研究了多段淋巴管中NO浓度分布、压力分布、NO平均浓度变化,以及3段管模型中各管的流量随时间变化情况.The lymphatic system plays an important part in the body’s immunity and cell’s internal environment homeostasis.Like a blood circulatory system,the lymphatic system is a piping system throughout the body,which is composed mainly of lymphatic fluid and lymphatic vessels.The spontaneous contraction of the lymphatic vessels drives the flow of lymphatic fluid in the vessels.The spontaneous contraction-relaxation mechanism of lymphatic vessels is determined by the oscillating feedback of Ca^(2+)concentration and NO concentration.The distribution of NO in the vessels plays an important role in the contraction cycle of lymphatic vessels.The shear force acting on the lymphatic valves due to the flow of fluid is the main source of NO.In a real system,the distribution of NO in a certain section of lymphatic vessel will be affected by other lymphanion connected to it,especially the upstream connecting fragments.Through the lattice Boltzmann method,a multi-segment lymphatic vessel model with valve structure is established,which reproduces the feedback mechanism of Ca^(2+)and NO,valve change and fluid flow.There are three types of lymphatic vessels in the model,namely the initial lymphatic vessel,the collecting lymphatic vessel,and the outlet lymphatic vessel.The number of lymphatic vessels can be unlimited and inputted by the parameters.The number of lymphatic vessels is 3-5,and there are two pairs of valves in each lymphatic vessel.In this paper studied are the distribution of NO and pressure in multi-segment lymphatic vessel,and the change in the flow of each vessel in the three-segment vessel model over time.

关 键 词：多段淋巴管 晶格玻尔兹曼方法 淋巴瓣膜 一氧化氮 流量 

分 类 号：R322.26[医药卫生—人体解剖和组织胚胎学]