芎归六君子汤治疗急性心肌梗死疗效及对患者再灌注损伤后心功能、氧化应激水平的影响  

Effect of Xionggui Liujunzi decoction on cardiac function and oxidative stress level in patients with acute myocardial infarction after reperfusion injury

作　　者：王朝歆[1] 李岩[1] 王超[1] 薛晓轩[1] 李文华[1] 苑舒淇 刘艳[1] 陆峥[1] 杨玲[1] WANG Chaoxin;LI Yan;WANG Chao;XUE Xiaoxuan;LI Wenhua;YUAN Shuqi;LIU Yan;LU Zheng;YANG Ling(Oriental Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《陕西中医》2021年第11期1549-1552,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助面上项目(81973622);北京中医药大学东方医院1166人才培养项目(030903010309)。

摘　　要：目的:探讨芎归六君子汤对急性心肌梗死患者再灌注损伤后心功能及氧化应激水平的影响。方法:将80例急性心肌梗死患者再灌注损伤后作为研究对象,采用随机数字表法分为对照组和研究组各40例,对照组给予常规治疗,研究组在对照组治疗基础上给予芎归六君子汤治疗。记录两组治疗前后的心功能、氧化应激水平、心肌肌钙蛋白I、肌酸激酶同工酶、中医证候积分,统计疗效。结果:治疗前,两组心功能、氧化应激水平、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、中医证候积分比较差异无统计学意义(P>0.05);治疗后,两组心功能、氧化应激水平、cTnI、CK-MB、中医证候积分均较治疗前改善,与对照组相比,研究组疗效、心功能、氧化应激水平、cTnI、CK-MB、中医证候积分改善更明显(P<0.05)。结论:芎归六君子汤能够有效改善急性心肌梗死患者再灌注损伤后心功能,调节氧化应激水平。Objective:This study aimed to investigate the effect of Xionggui Liujunzi decoction on cardiac function and oxidative stress levels in patients with acute myocardial infarction after reperfusion injury.Methods:80 admitted patients with acute myocardial infarction after reperfusion injury were taken as the research object.They were divided into a control group and a study group with 40 cases each by a random number table method.The control group was given for conventional treatment,the study group was given Xionggui Liujunzi decoction on the basis of the treatment of the control group.The heart function,oxidative stress level,cardiac troponin I,creatine kinase isoenzyme,TCM syndrome scores before and after treatment were recorded in the two groups,and the curative effect was calculated.Results:Before treatment,the two groups’heart function,oxidative stress level,cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB),TCM syndrome scores were compared(P>0.05);after treatment,the two groups’heart function,oxidative stress level,cTnI,CK-MB,the scores of TCM syndromes were improved compared with those before treatment.Compared with the control group,the scores of efficacy,heart function,oxidative stress,cTnI,CK-MB,and TCM syndromes of the study group improved significantly(P<0.05).Conclusion:Xionggui Liujunzi decoction can effectively improve the heart function of patients with acute myocardial infarction after reperfusion injury and regulate the level of oxidative stress.

关 键 词：急性心肌梗死 再灌注损伤 芎归六君子汤 心功能 氧化应激 心肌肌钙蛋白Ⅰ 肌酸激酶同工酶 

分 类 号：R542.22[医药卫生—心血管疾病]