基于“双心疾病”理论探讨舒心口服液联合西医常规 疗法治疗稳定性冠心病合并焦虑的临床疗效  

Clinical efficacy of Shuxin Oral Liquid combined with conventional western medicine in the treatment of stable coronary heart disease with anxiety based on“psycho-cardiology disease”theory

作　　者：王俊力[1,2] 李立为[3] 田强强 张蓓蓓 龚雪 徐金梅 梅俊华[2] WANG Junli;LI Liwei;TIAN Qiangqiang;ZHANG Beibei;GONG Xue;XU Jinmei;MEI Junhua(Hubei University of Chinese Medicine,Wuhan 430065,Hubei,China;Department of Neurology,Wuhan No.1 Hospital,Wuhan 430022,Hubei,China;Department of Cardiovascular Medicine,Wuhan No.1 Hospital,Wuhan 430022,Hubei,China;Department of Cardiovascular Medicine,Hubei Provincial Hospital of TCM,Wuhan 430061,Hubei,China;Department of Neurology,Hubei Provincial Hospital of TCM,Wuhan 430061,Hubei,China)

机构地区：[1]湖北中医药大学,湖北武汉430065 [2]武汉市第一医院神经内科,湖北武汉430022 [3]武汉市第一医院心血管内科,湖北武汉430022 [4]湖北省中医院心血管内科,湖北武汉430061 [5]湖北省中医院神经内科,湖北武汉430061

出　　处：《上海中医药大学学报》2021年第5期14-19,共6页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：湖北省卫计委科研项目(2017-2018-35)。

摘　　要：目的:基于中医学“双心疾病”理论,探讨舒心口服液联合西医常规疗法治疗稳定性冠心病(SCHD)合并焦虑的临床疗效。方法:纳入90例SCHD合并焦虑患者,随机分为治疗组和对照组,每组各45例。两组患者均给予常规西药治疗,同时治疗组患者给予舒心口服液治疗,治疗周期为12周。治疗前及治疗4周、12周时,记录患者的心绞痛发作次数及硝酸甘油用量,并采用自拟中医证候积分量表、汉密尔顿焦虑量表(HAMA)、西雅图心绞痛调查表(SAQ)评估患者的临床症状、情绪状态及生活质量。结果:研究过程中,治疗组2例患者、对照组2例患者被剔除或脱落,最终治疗组43例、对照组43例患者纳入统计分析。①治疗4周、12周时,两组患者的心绞痛发作次数及硝酸甘油用量较治疗前均明显减少(P<0.05),且治疗组患者的心绞痛发作次数及硝酸甘油用量较对照组亦明显减少(P<0.05)。②治疗4周、12周时,治疗组患者的HAMA总分及心血管系统因子评分较治疗前均明显降低(P<0.05),且治疗组患者的评分较对照组亦明显降低(P<0.05)。③治疗4周、12周时,两组患者的中医证候总积分及胸痛、心悸、气短积分较治疗前均明显减少(P<0.05),且治疗组患者的积分均低于对照组(P<0.05)。④治疗4周、12周时,两组患者的SAQ各维度积分较治疗前均明显升高(P<0.05),且治疗组患者的SAQ各维度积分较对照组亦明显升高(P<0.05)。结论:基于中医学“双心疾病”理论,以舒心口服液联合西医常规疗法治疗SCHD合并焦虑患者,可明显改善患者的临床症状及焦虑情绪,提高患者的生活质量。Objective:To explore the clinical efficacy of Shuxin Oral Liquid combined with conventional western medicine in the treatment of stable coronary heart disease(SCHD)with anxiety based on“psycho-cardiology disease”theory in traditional Chinese medicine(TCM).Methods:A total of 90 SCHD patients with anxiety were included and randomly divided into the treatment group and control group,45 cases in each group.The patients in both groups were treated with conventional western medicine,meanwhile the patients in the treatment group were treated with Shuxin Oral Liquid.The treatment course was 12 weeks.Before treatment and 4 and 12 weeks after treatment,the frequency of angina attack and the nitroglycerin dosage were recorded,and the self-made TCM syndrome score scale,Hamilton anxiety(HAMA)scale and Seattle angina questionnaire(SAQ)were applied to evaluate the clinical symptoms,emotional state and quality of life.Results:During the study,2 patients in the treatment group and 2 patients in the control group were eliminated or fell off.Finally 43 cases in the treatment group and 43 cases in the control group were included for the statistical analysis.①Four and twelve weeks after treatment,the frequency of angina attack and the nitroglycerin dosage were significantly reduced in both groups compared with those before treatment(P<0.05),and the frequency of angina attack and the nitroglycerin dosage in the treatment group were significantly less than those in the control group(P<0.05).②Four and twelve weeks after treatment,the total score and cardiovascular system factor score of HAMA were significantly decreased in the treatment group compared with those before treatment(P<0.05),and the scores of the treatment group were obviously lower than those of the control group(P<0.05).③Four and twelve weeks after treatment,the total score of TCM syndromes and the scores of chest pain,palpitation and short breath were significantly reduced in both groups compared with those before treatment(P<0.05),and the scores of the treatmen

关 键 词：稳定性冠心病 焦虑 双心疾病 舒心口服液 中西医结合 

分 类 号：R541.4[医药卫生—心血管疾病] R749.72[医药卫生—内科学]