血清VEGF及TGF-β1水平预测妊娠期糖尿病孕妇自发性早产的价值  

Predictive value of levels of VEGF and TGF-β1 for spontaneous preterm delivery in pregnant women with gestational diabetes mellitus

作　　者：张秋妍 朱改变[1] Zhang Qiuyan;Zhu Gaibian(Department of Obstetrics,Shanxi Maternal and Child Health Care Hospital,Taiyuan 030013,China)

机构地区：[1]山西省妇幼保健院产科,太原030013

出　　处：《中国实用医刊》2021年第17期38-41,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清血管内皮生长因子(VEGF)、转化生长因子β1(TGF-β1)水平对妊娠期糖尿病(GDM)孕妇自发性早产的预测价值。方法抽取2018年1月至2020年12月在山西省妇幼保健院进行产检并完成分娩的165例GDM孕妇为研究对象,将其中发生自发性早产的14例GDM孕妇纳入自发性早产组,未发生自发性早产的151例孕妇纳入未发生自发性早产组。比较两组孕妇孕中期血清VEGF、TGF-β1水平,绘制受试者工作特征曲线,分析血清VEGF、TGF-β1水平对GDM孕妇发生自发性早产的预测价值。结果自发性早产组孕中期血清VEGF、TGF-β1水平分别为(27.35±6.28)ng/L、(66.49±13.56)μg/L,均高于未发生自发性早产组的(19.36±4.27)ng/L、(47.39±11.58)μg/L,P<0.05。绘制受试者工作特征曲线结果显示,孕中期血清VEGF、TGF-β1水平单独及联合预测GDM孕妇自发性早产发生风险的曲线下面积均>0.70,预测价值较理想,且以联合预测价值最佳。结论血清VEGF、TGF-β1过表达对GDM孕妇自发性早产发生风险具有一定预测价值,二者过表达提示自发性早产发生风险较高。Objective To investigate the predictive value of the levels of vascular endothelial growth factor(VEGF)and transforming growth factorβ1(TGF-β1)for spontaneous preterm delivery in pregnant women with gestational diabetes mellitus(GDM).Methods A total of 165 GDM pregnant women who completed delivery in Shanxi Maternal and Child Health Hospital from January 2018 to December 2020 were selected as the research objects.Among them,14 GDM pregnant women with spontaneous premature delivery were included in the spontaneous premature delivery group,and 151 pregnant women without spontaneous premature delivery were included in the non spontaneous premature delivery group.The levels of VEGF and TGF-β1 in the second trimester of pregnancy were compared between the two groups.Receiver operating characteristic(ROC)curve was drawn to analyze predictive value of serum VEGF and TGF-β1 levels for spontaneous premature delivery in GDM pregnant women.Results The serum levels of VEGF and TGF-β1 in the spontaneous preterm delivery group were(27.35±6.28)ng/L and(66.49±13.56)μg/L,respectively,higher than the(19.36±4.27)ng/L and(47.39±11.58)μg/L in non-spontaneous premature delivery group(P<0.05).The ROC curve showed that the area under the curve of serum VEGF only,TGF-β1 only,and combination of them in the second trimester of pregnancy in predicting the risk of spontaneous preterm delivery of GDM pregnant women were all more than 0.70,suggesting ideal predictive value;and the predictive value of VEGF combined with TGF-β1 was the best.Conclusions Overexpression of VEGF and TGF-β1 can predict the risk of spontaneous preterm delivery in GDM pregnant women.Overexpression of VEGF and TGF-β1 suggests a higher risk of spontaneous preterm delivery.

关 键 词：妊娠期糖尿病 自发性早产 血管内皮生长因子 转化生长因子Β1 预测价值 

分 类 号：R714.256[医药卫生—妇产科学] R714.21[医药卫生—临床医学]