高压氧联合布地奈德福莫特罗粉吸入剂对支气管哮喘患者肺功能及血气指标的影响  

Effect of hyperbaric oxygen combined with budesonide and formoterol fumarate powder for inhalation on lung function and blood gas index in patients with bronchial asthma

作　　者：李琳[1] 金鹏[2] Li Lin;Jin Peng(Department of Respiratory and Critical Care,Luohe Central Hospital,Luohe 462000,China;Department of Cardiology,Luohe Central Hospital,Luohe 462000,China)

机构地区：[1]河南省漯河市中心医院呼吸与危重症科,462000 [2]河南省漯河市中心医院心内科,462000

出　　处：《中国实用医刊》2021年第17期71-74,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨高压氧联合布地奈德福莫特罗粉吸入剂对支气管哮喘患者肺功能及血气指标的影响。方法回顾性分析2019年1月至2019年12月漯河市中心医院收治的80例支气管哮喘患者的临床资料。根据治疗方式将患者分为两组,观察组(40例)采用常规治疗、高压氧联合布地奈德福莫特罗粉吸入剂,对照组(40例)采用常规治疗联合布地奈德福莫特罗粉吸入剂治疗。治疗前后,测定并比较两组肺功能指标[第1秒用力呼气容积占预测值百分比(FEV1%)、第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC)]及血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、免疫功能指标(CD3^(+)、CD4^(+))。结果治疗前,两组FEV1%、FEV1/FVC比较差异未见统计学意义(P>0.05);治疗后,两组FEV1%、FEV1/FVC均较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组PaO_(2)、PaCO_(2)比较差异未见统计学意义(P>0.05)。治疗后,两组PaO_(2)升高,PaCO_(2)降低(P<0.05);且观察组PaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05)。治疗前,两组CD3^(+)、CD4^(+)比较差异未见统计学意义(P>0.05);治疗后,两组CD3^(+)、CD4^(+)较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论高压氧联合布地奈德福莫特罗粉吸入剂治疗支气管哮喘患者,可提高其肺功能,改善血气指标,提升免疫功能,促进疾病转归。Objective To investigate the effect of hyperbaric oxygen combined with budesonide and formoterol fumarate powder for inhalation on patients with bronchial asthma.Methods The clinical data of 80 patients with bronchial asthma treated in Luohe Central Hospital from January 2019 to December 2019 were retrospectively analyzed.The patients were divided into two groups according to treatment methods.The observation group(40 cases)was treated by conventional therapy,hyperbaric oxygen,and budesonide and formoterol fumarate powder for inhalation;the control group(40 cases)was treated by conventional therapy combined with budesonide and formoterol fumarate powder for inhalation.Before and after treatment,pulmonary function indexes,including percent predicted forced expiratory volume in 1 second(FEV1%),forced expiratory volume in 1 second/forced vital capacity(FEV1/FVC),blood gas indexes,including arterial partial pressure of oxygen(PaO_(2))and arterial partial pressure of carbon dioxide(PaCO_(2)),immune function indexes,assessed by cluster of differentiasion(CD)3^(+)and CD4^(+),were measured and compared between the two groups.Results Before treatment,there was no significant difference in FEV1%and FEV1/FVC between the two groups(P>0.05).After treatment,FEV1%and FEV1/FVC of the two groups were higher than those before treatment,and the postoperative FEV1%and FEV1/FVC of observation group were higher than those of control group(P<0.05).Before treatment,there was no significant difference in PaO_(2)and PaCO_(2)between the two groups(P>0.05).After treatment,PaO_(2)increased,and PaCO_(2)decreased in the two groups(P<0.05);and the PaO_(2)of the observation group was higher,and the PaCO_(2)was lower,compared with those of control group(P<0.05).Before treatment,there was no significant difference in CD3^(+)and CD4^(+)between the two groups(P>0.05).After treatment,CD3^(+)and CD4^(+)increased in the two groups,and the observation group had higher CD3^(+)and CD4^(+)than the control group(P<0.05).Conclusions Hyperbaric oxygen combine

关 键 词：支气管哮喘 高压氧 布地奈德福莫特罗粉吸入剂 肺功能 血气指标 免疫功能 

分 类 号：R562.25[医药卫生—呼吸系统]