调控人多能干细胞来源心肌样细胞分化成熟的信号通路及其相关化合物研究进展  

Research Progress of Signaling Pathways and Related Compounds Regulating the Differentiation and Maturation of Human Pluripotent Stem Cell-Cardiomyocytes

作　　者：刘经纶 秦丽颖 廖凌子 赵兴坤 刘瑞敏[3] LIU Jinglun;QIN Liying;LIAO Lingzi;ZHAO Xingkun;LIU Ruimin(School of Stomatology,Lanzhou University,Lanzhou 730000,China;the Second Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Oral and Maxillofacial Surgery,Gansu Provincial People's Hospital,Lanzhou 730000,China)

机构地区：[1]兰州大学口腔医学院,兰州730000 [2]兰州大学第二临床医学院,兰州730000 [3]甘肃省人民医院口腔颌面外科,兰州730000

出　　处：《中国细胞生物学学报》2021年第9期1861-1868,共8页Chinese Journal of Cell Biology

基　　金：甘肃省自然科学基金(批准号:2019-0405-JCC-0208)资助的课题。

摘　　要：由人多能干细胞分化而来的心肌细胞具备良好的基础研究与临床治疗前景,但其结构与功能的不成熟限制了其发展。功能化合物可以直接作用于人多能干细胞向心肌细胞分化成熟过程中的信号通路。添加功能化合物是一种简单、有效、可重复性好的方法。许多团队在促进人多能干细胞向心肌分化成熟的信号通路与功能化合物研究方面取得了实质性的科研进展,该文针对这两方面作出综述,以期为后续实验提供指导。Cardiomyocytes derived from human pluripotent stem cells have a good prospect for basic research and clinical treatment,but their development is limited by their immature structure and function.Functional compounds can directly act on the signaling pathway during the differentiation and maturation of human pluripotent stem cells into cardiomyocytes.Adding functional compounds is a simple,effective and reproducible method.Many groups have made substantial research progress on the signaling pathways and functional compounds that promote the differentiation and maturation of human pluripotent stem cells into myocardium.This paper reviews these two aspects in order to provide guidance for future experiments.

关 键 词：人多能干细胞 心肌分化成熟 信号通路 功能化合物 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]