TRPC6与心血管疾病关系的研究进展  

Research Progress on the Relationship between TRPC6 and Cardiovascular Diseases

作　　者：谈远佳 张世忠[1] TAN Yuanjia;ZHANG Shizhong(Medical College of China Three Gorges University,Yichang 443000,China)

机构地区：[1]三峡大学医学院,宜昌443000

出　　处：《中国细胞生物学学报》2021年第9期1869-1875,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:30872716);湖北省自然科学基金(批准号:2015CFB288);湖北省卫生与计划生育项目(批准号:WJ2015MB171)资助的课题。

摘　　要：瞬时受体电位通道6(transient receptor potential cation channel 6,TRPC6)是瞬时受体电位离子通道家族的成员之一,属于非选择性阳离子通道。TRPC6广泛分布于大脑、神经、心脏、血管、肺、肾、胃肠道等器官组织中,可被渗透压变化、机械刺激、二酰基甘油激活,进而参与体内多种疾病的病理生理过程。研究发现,TRPC6的失调与心血管系统疾病的发病机制关系密切,且TRPC6与心血管疾病关系的研究成为近来热点。该文主要介绍TRPC6的结构特点及其与心血管系统相关疾病关系的最新研究进展。TRPC6 (transient receptor potential cation channel 6) is one of the members of transient receptor potential ion channels,which is a non-selective cation channel.TRPC6 is widely distributed in organs and tissues such as the brain,nerves,heart,blood vessels,lung,kidney,gastrointestinal tract,etc.It can be activated by osmotic pressure change,mechanical stimulation and diacylglycerol,and then participates in the pathophysiological processes of many diseases in the body.Studies have found that the disorder of TRPC6 is closely related to the pathogenesis of cardiovascular diseases,and the relationships between TRPC6 and cardiovascular diseases have become research hotspots.This article mainly introduces the structural characteristics of TRPC6 and the latest research progress in its relationship with cardiovascular system-related diseases.

关 键 词：TRPC6 心血管疾病 心肌缺血再灌注损伤 心肌肥厚 心肌纤维化 高血压 

分 类 号：R54[医药卫生—心血管疾病]