蛋白质核质转运的过程和应用  

The Process and Application of Nucleocytoplasmic Transport of Proteins

作　　者：但德苗 郭忠建[1] DAN Demiao;GUO Zhongjian(Institute of Life Sciences,Jiangsu University,Zhenjiang 212000,China)

机构地区：[1]江苏大学,生命科学研究院,镇江212000

出　　处：《中国细胞生物学学报》2021年第9期1891-1900,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31370184、31770174)资助的课题。

摘　　要：真核生物区别于原核生物的特征之一是存在被核膜包被的细胞核。核膜是一种磷脂双分子膜,由内膜和外膜组成,对蛋白质转运具有高度的选择性。核膜上嵌有核孔复合体,其是完成细胞核内外蛋白质转运所必需的。除此之外,该过程还需转运受体蛋白、Ran系统以及货物蛋白自身的结构协同参与完成。该文着重就真核生物蛋白核质转运的机制及近年来转运受体蛋白在肿瘤治疗中的临床应用进行综述。One of the characteristics that distinguish eukaryotes from prokaryotes is the presence of the nuclei.The NE (nuclear envelope) is a phospholipid bimolecular membrane,including inner membrane and outer membrane.The NPC (nuclear pore complex) embedded in the NE is necessary for the process of transportation of some proteins through the NE.In addition,the process also requires the coordination of the transport receptor protein,the Ran system,and the structure of cargo protein.This article focuses on the process and mechanism of eukaryotic nucleocytoplasmic transport and the clinical application of transport receptor proteins in tumor therapy in recent years.

关 键 词：核孔复合体 转运受体蛋白 NLS/NES Ran系统 肿瘤 

分 类 号：Q243[生物学—细胞生物学]