中药复方治疗脾虚血瘀证骨质疏松症用药规律研究  

Study on Rule of Medication for Patients with Osteoporosis of Spleen Deficiency and Blood Stasis Syndrome

作　　者：张鸿秋[1,2] 陈莉 洪安娟[1] 方朝晖[3] ZHANG Hongqiu;CHEN Li;HONG Anjuan;FANG Zhaohui(Fuyang People’s Hospital,Fuyang 236000,Anhui,China;Fuyang Clinical College,Anhui Medical University,Fuyang 236000,Anhui,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,Anhui,China)

机构地区：[1]阜阳市人民医院,安徽阜阳236000 [2]安徽医科大学阜阳临床学院,安徽阜阳236000 [3]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中华中医药学刊》2021年第9期32-35,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81774286)。

摘　　要：目的探讨中药复方治疗脾虚血瘀证骨质疏松症处方的用药规律。方法收集医院采用中药治疗脾虚血瘀证骨质疏松症患者病案资料,通过数据挖掘技术、关联规则和聚类分析中药治疗的频次、四气五味归经、核心药物、药对、处方等。结果共搜集处方213首,含药131味。有茯苓、陈皮、红花、丹参、薏苡仁、甘草应用频次超过50%;温性、热性药55味,甘味药50味,入脾胃经药86味。复杂网络图显示茯苓、威灵仙、山药、陈皮、蒲公英、红花、桃仁、甘草、薏苡仁、丹参10味为核心药物。中药药对关联规则显示茯苓-豨签草、红花-桃仁、茯苓-姜半夏/薏苡仁、红花-威灵仙/桃仁等为常用药对。得到桃仁-红花-丹参、蒲公英、白花蛇舌草、威灵仙、豨签草等5个聚类方。结论总结应用健脾活血中药治疗脾虚血瘀证骨质疏松症患者的用药规律。Objective To explore the medication rule of traditional Chinese medicine compound prescription for the treatment of osteoporosis of spleen deficiency and blood stasis syndrome. Methods The medical records of patients with osteoporosis of spleen deficiency and blood stasis syndrome treated with traditional Chinese medicine in our hospital were collected, and we analyzed the frequency, four tastes and five natures, core drugs, drug pairs and prescriptions of traditional Chinese medicine through data mining technology, association rules and clustering analysis. Results A total of 213 prescriptions were collected, containing 261 drugs. The frequency of Fuling(Poria),Chenpi(Citri Reticulatae Pericarpium),Honghua(Carthami Flos),Danshen(Salviae Miltiorrhizae Radix Et Rhizoma),Yiyiren(Coicis Semen) and Gancao were more than 50%. There were 55 warm and heat drugs and 50 sweat drugs. And 86 drugs were related to stomach and spleen meridians. The complex network diagram showed that Fuling(Poria),Weilingxian(Clematidis Radix Et Rhizoma),Shanyao(Dioscoreae Rhizoma)(Dioscoreae Rhizoma),Chenpi(Citri Reticulatae Pericarpium),Pugongying(Taraxaci Herba),Honghua(Carthami Flos),Taoren(Persicae Semen),Gancao(Glycyrrhizae Radix Et Rhizoma),Yiyiren(Coicis Semen) and Danshen(Salviae Miltiorrhizae Radix Et Rhizoma) were the core drugs. The association rules of traditional Chinese medicine pairs showed that Fuling(Poria)-Xixiancao(Siegesbeckiae Herba), Honghua(Carthami Flos)-Taoren(Persicae Semen), Fuling(Poria)-Jiangbanxia and Yiyiren(Coicis Semen), Honghua(Carthami Flos)-Weilingxian(Clematidis Radix Et Rhizoma) and Taoren(Persicae Semen) were commonly used drug pairs. Five clusters prescriptions were Taoren(Persicae Semen)-Honghua(Carthami Flos)-Danshen(Salviae Miltiorrhizae Radix Et Rhizoma),Pugongying(Taraxaci Herba),Baihuasheshecao(Hedyotidis Herba),Weilingxian(Clematidis Radix Et Rhizoma) and Xixiancao(Siegesbeckiae Herba). Conclusion The medication rules of traditional Chinese medicine for strengthening spleen and promoting blood c

关 键 词：骨质疏松症 脾虚血瘀证 数据挖掘 健脾活血 茯苓 

分 类 号：R269.81[医药卫生—中西医结合]