补肺化瘀通络汤加减治疗慢性阻塞性肺疾病急性发作期对肺表面活性蛋白、血气指标水平影响  

Effect of Bufei Huayu Tongluo Decoction(补肺化瘀通络汤)on Pulmonary Surfactant Protein and Blood Gas Indexes in Patients with Acute Attack of COPD

作　　者：张守军 周蕾[1] 李冰[1] ZHANG Shoujun;ZHOU Lei;LI Bing(Tangshan Workers Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市工人医院,河北唐山063000

出　　处：《中华中医药学刊》2021年第9期44-47,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研项目(20170686);河北省中医药管理局项目(2014272)。

摘　　要：目的分析补肺化瘀通络汤加减治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)急性发作期对患者肺表面活性蛋白(SP-D)、血气指标水平影响。方法选取医院2017年4月—2019年4月收治的COPD急性发作期患者104例,采用随机数字法分为两组。对照组给予西医常规对症治疗,观察组在对照组基础上给予补肺化瘀通络汤加减辅助治疗,分析两组患者治疗后的临床效果。结果观察组总有效率(92.31%,48/52)高于对照组(76.92%,40/52),不良反应率(11.54%,6/52)与对照组(7.69%,4/52)比较,差异不具有统计学意义(P>0.05)。两组治疗前相关细胞因子水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后杀菌/通透性增加蛋白(BPI)、白细胞介素-10(IL-10)水平高于对照组,肺表面活性蛋白(SP-D)、肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)水平低于对照组(P<0.05)。两组治疗前血气指标组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后动脉氧分压(PaO2)、血氧饱和度(SaO2)水平高于对照组,动脉二氧化碳分压(PaCO2)水平低于对照组(P<0.05)。结论补肺化瘀通络汤加减治疗COPD急性发作期可调节相关因子的表达水平,改善血气分析,提高疗效,且不增加不良反应。Objective To analyze the effect of Bufei Huayu Tongluo Decoction(补肺化瘀通络汤) on pulmonary surface active protein(SP-D) and blood gas index in patients with chronic obstructive pulmonary disease(COPD) during acute attack. Methods From April 2017 to April 2019, 104 patients with acute attack of COPD were randomly divided into two groups. The control group was treated with routine symptomatic treatment of western medicine, and the observation group was treated with Bufei Huayu Tongluo Decoction on the basis of the control group. The clinical effect of the two groups after treatment was analyzed. Results The total effective rate(92.31%,48/52) in the observation group was higher than that in the control group(76.92%,40/52), and the adverse reaction rate(11.54%,6/52) in the observation group was not significantly different from that in the control group(7.69%,4/52)(P>0.05). There was no significant difference in the level of related cytokines between the two groups before treatment(P>0.05). After treatment, the levels of bactericidal/permeability increasing protein(BPI) and IL-10 in the observation group were higher than those in the control group, while the levels of SP-D, tumor necrosis factor-α(TNF-α) and IL-17 were lower than those in the control group(P<0.05). There was no significant difference in blood gas index between the two groups before treatment(P>0.05). After treatment, the levels of arterial partial pressure of oxygen(PaO2) and blood oxygen saturation(SaO2) in the observation group were higher than those in the control group, and the level of arterial partial pressure of carbon dioxide(PaCO2) was lower than that in the control group(P<0.05).Conclusion The treatment of COPD with Bufei Huayu Tongluo Decoction can regulate the expressions of related factors, improve blood gas analysis and the curative effect, and does not increase the adverse reactions.

关 键 词：补肺化瘀通络汤 慢性阻塞性肺疾病 急性发作期 疗效 安全性 

分 类 号：R259.63[医药卫生—中西医结合]