葛根芩连汤加味结合针刺治疗急性胃肠炎疗效及对便轮状病毒转阴情况、炎症因子的变化  

Therapeutic Effect of Gegen Qinlian Decoction(葛根芩连汤)Combined with Acupuncture on Acute Gastroenteritis Patients and Changes of Inflammatory Factors and Negative Conversion of Rotavirus in Patients with Acute Gastroenteritis

作　　者：林海 许青青 林孔万 LIN Hai;XU Qingqing;LIN Kongwan(Hainan Hospital of Traditional Chinese Medicine,Haikou 570203,Hainan,China)

机构地区：[1]海南省中医院,海南海口570203

出　　处：《中华中医药学刊》2021年第9期55-57,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81960227)。

摘　　要：目的对葛根芩连汤加味结合针刺对急性胃肠炎患者的疗效及患者便轮状病毒转阴情况、炎症因子的变化进行探讨。方法收集医院在2017年6月—2019年12月期间收治的急性胃肠炎患者136例为研究对象,依据治疗方法的不同分为研究组与对照组。其中对照组68例采用常规的治疗方法,研究组68例则在对照组基础上采用葛根芩连汤加味结合针刺的治疗方法,对两组患者治疗后临床疗效进行比较分析。结果经过治疗后,研究组总有效率、粪便镜检白细胞复常率[分别为92.65%(63/68),100.00%(68/68)]均高于对照组[分别为80.88%(55/68),94.12%(64/68)],差异具有统计学意义(P<0.05)。研究组治疗3、5 d时便轮状病毒转阴率分别为83.82%(57/68),100.00%(68/68),对照组分别为70.59%(48/68),88.23%(60/68)。研究组治疗3 d、5 d时便轮状病毒转阴率高于对照组(P<0.05)。两组治疗前内毒素、超敏-C反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞介素-2(IL-2)水平组间比较,差异无统计学意义(P>0.05)。研究组治疗后IL-2水平高于对照组,内毒素、hs-CRP、PCT水平低于对照组(P<0.05)。结论葛根芩连汤加味结合针刺治疗急性胃肠炎可减轻机体炎症反应,提高便轮状病毒转阴率和粪便镜检白细胞复常率,且安全性高。Objective To analyze the curative effect of Gegen Qinlian Decoction(葛根芩连汤) combined with acupuncture on acute gastroenteritis patients and the effect of rotavirus negative conversion and the change of inflammatory factors in patients with acute gastroenteritis. Methods A total of 136 patients with acute gastroenteritis admitted in our hospital from June 2017 to December 2019 were divided into study group and control group according to different treatment methods. Among them, 68 cases in the control group were treated with conventional methods, and 68 cases in the study group were treated with Gegen Qinlian Decoction combined with acupuncture on the basis of the control group. The clinical effects of the two groups were compared and analyzed. Results The total effective rate and leukocyte normalization rate[92.65%(63/68), 100.00%(68/68)] in observation group were higher than those in control group[80.88%(55/68), 94.12%(64/68)] and the difference was statistically significant(P<0.05). The seroconversion rates of rotavirus were 83.82%(57/68) and 100.00%(68/68) in the observation group and 70.59%(48/68) and 88.23%(60/68) in the control group respectively on the 5 th day after treatment. The seroconversion rate of rotavirus in the observation group was significantly higher than that in the control group(P<0.05). Before treatment, the levels of endotoxin, hypersensitive-C reactive protein(hs-CRP) and procalcitonin(PCT) in the two groups were higher than those in the control group(P<0.05). There was no significant difference in the level of interleukin-2(IL-2) between groups(P>0.05). The levels of IL-2, endotoxin, hs-CRP and PCT in the observation group after treatment were higher than those in the control group. It was lower than that in the control group(P<0.05). Conclusion The combination of Gegen Qinlian Decoction and acupuncture in the treatment of acute gastroenteritis can reduce the inflammatory reaction, improve the negative rate of rotavirus and the rate of leukocyte normalization in stool microscopic

关 键 词：葛根芩连汤 针刺 急性胃肠炎 便轮状病毒 炎症因子 

分 类 号：R259.733[医药卫生—中西医结合] R245.31[医药卫生—中医内科学]