火绒草属植物的化学成分和药理活性  

Chemical Constituents and Pharmacological Activities of Leontopodium Plants

作　　者：唐馨[1] 展锐[1] 谢海辉[2] 苟萍[1] TANG Xin;ZHAN Rui;XIE Haihui;GOU Ping(College of Life Sciences and Technology,Xinjiang University,Uruniqi 830046,Xinjiang,China;South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650,Guangdong,China)

机构地区：[1]新疆大学生命科学与技术学院,新疆乌鲁木齐830046 [2]中国科学院华南植物园,广东广州510650

出　　处：《中华中医药学刊》2021年第9期95-99,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(31460081)。

摘　　要：火绒草属植物在民间医药中广泛应用。近年来从火绒草属中发现了不少具有多种药理活性的化合物。着重概括和阐述新近发现的化合物及其药理作用。现已明确火绒草中一些单体化合物的体外活性,黄酮类和苯丙素类化合物具有降糖作用,苯丙素类中的酚酸类化合物具有抗炎活性,异苯并呋喃酮类、萜类和另外几种苯丙素类(降糖和抗炎活性的除外)化合物具有降脂作用,葡萄糖二酸类化合物(leontopodic acid)具有良好的抗氧化作用。为火绒草属进一步的研究和开发利用提供翔实的资料。Plants of Leontopodium have long been widely used in folk medicine. Several compounds were isolated from Leontopodium with a broad spectrum of pharmacological activities. In this paper, the newly discovered compounds and their pharmacological effects were summarized. Flavonoids and phenylpropanoids have hypoglycemic effects. Phenolic acids in phenylpropanoids have anti-inflammatory activities. Isobenzofuranones, terpenes and other phenylpropanoids(except those with hypoglycemic and anti-inflammatory activities) have lipid-lowering effects. Leontopodic acid has good antioxidant activity. This paper provides detailed information for further research and development of Leontopodium.

关 键 词：火绒草 化学成分 药理活性 

分 类 号：R284.1[医药卫生—中药学]