疏肝和胃加减汤治疗慢性萎缩性胃炎疗效及对病理组织及血清炎性因子指标改善的研究  

Effect of Shugan Hewei Decoction(疏肝和胃加减汤)in Treatment of Chronic Atrophic Gastritis and Improvement of Pathological Tissue and Serum Inflammatory Factors

作　　者：黎玉仙 陈秀芳[1] 金明娣 LI Yuxian;CHEN Xiufang;JIN Mingdi(Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 311201,Zhejiang,China)

机构地区：[1]浙江中医药大学附属江南医院,浙江杭州311201

出　　处：《中华中医药学刊》2021年第9期200-203,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划(2016ZB111)。

摘　　要：目的探讨疏肝和胃加减汤治疗慢性萎缩性胃炎治疗前后患者病理组织及血清炎性因子指标改善情况。方法选取医院2013年5月—2020年5月收治的100例慢性萎缩性胃炎患者,随机将患者分为研究组50例,对照组50例。对照组患者给予奥美拉唑、胃复春片治疗,研究组患者给予疏肝和胃加减汤治疗。对比两组患者治疗前后病理组织学评分;对比两组患者治疗前后胃脘胀痛、恶心呕吐、气滞食积、嗳气吞酸等中医证候改善情况;对比两组患者治疗前后C反应蛋白、血清胆碱酯酶(serum cholinesterase, S-ChE)、成纤维细胞生长因子23(fibroblast growth factor 23,FGF-23)等血清炎性因子改善情况;对比两组患者治疗过程中恶心呕吐、食欲减退加重、过敏性皮炎、消化道痉挛不良反应发生率;对比两组患者临床治疗总有效。结果研究组患者治疗后病理组织学评分明显低于对照组患者,对比差异具有统计学意义(P<0.05);研究组患者治疗后胃脘胀痛、恶心呕吐、气滞食积、嗳气吞酸等中医证候指标评分明显低于对照组患者,对比差异具有统计学意义(P<0.05);研究组患者治疗后C反应蛋白,FGF-23水平明显低于对照组患者,S-ChE水平明显高于对照组患者,对比差异均有统计学意义(P<0.05);研究组患者食欲减退加重、过敏性皮炎、消化道痉挛等不良反应发生率明显低于对照组患者,对比差异具有统计学意义(P<0.05);研究组患者临床治疗总有效率98%(49/50)明显高于对照组患者88%(44/50),对比差异具有统计学意义(P<0.05)。结论疏肝和胃加减汤治疗慢性萎缩性胃炎不良反应小,病理组织学改善明显,有效调节机体血清炎性因子指标,明显提高临床疗效及有效率,值得推广及应用。Objective To investigate the clinical effect of Shugan Hewei Decoction(疏肝和胃加减汤) on chronic atrophic gastritis. Methods A total of 100 cases of chronic atrophic gastritis patients in our hospital from May 2013 to May 2020 were selected and randomly divided into study group(50 cases) and control group(50 cases). The control group was treated with omeprazole and Weifuchun Tablets and the study group was treated with Shugan Hewei Decoction. The histopathological scores of the two groups before and after treatment were compared. The improvement of TCM syndromes such as epigastric pain, nausea and vomiting, Qi stagnation and food retention, belching and acid swallowing were compared between the two groups before and after treatment. C-reactive protein, nausea and vomiting, Qi stagnation and food retention, belching and acid swallowing were compared between the two groups before and after treatment. The improvement of S-ChE, FGF-23 and other serum inflammatory factors and the incidence of nausea and vomiting, anorexia, allergic dermatitis, gastrointestinal spasm and other adverse reactions were compared between the two groups. The total effective rate of clinical treatment was compared between the two groups. Results After treatment, the histopathological score of the study group was significantly lower than that of the control group and the difference was statistically significant(P<0.05). After treatment, the scores of stomachache, nausea and vomiting, Qi stagnation and food retention, belching and acid swallowing in the study group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05). The level of C-reactive protein of the study group after treatment was significantly lower than that of the control group. The FGF-23 level was significantly lower than that of the control group. The S-ChE level was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). The incidence of anorexia, allergic d

关 键 词：疏肝和胃加减汤 慢性萎缩性胃炎 病理组织学 血清炎性因子 

分 类 号：R259.733.2[医药卫生—中西医结合]