逐瘀通脉胶囊结合尼莫地平治疗老年慢性脑供血不足临床疗效研究  

Study on Clinical Efficacy and Safety of Zhuyu Tongmai Capsule(逐瘀通脉胶囊)Combined with Nimodipine in Treatment of Chronic Cerebral Insufficiency in The Elderly

作　　者：郁洁[1] 洪侃[1] 王卓[1] 陆守荣[1] 张炳山[1] 杨颖[1] YU Jie;HONG Kan;WANG Zhuo;LU Shourong;ZHANG Bingshan;YANG Ying(Wuxi Peoples Hospital,Nanjing Medical University,Wuxi 214000,Jiangsu,China)

机构地区：[1]南京医科大学附属无锡市人民医院,江苏无锡214000

出　　处：《中华中医药学刊》2021年第9期208-211,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省自然科学基金(BK20160193)。

摘　　要：目的探究逐瘀通脉胶囊结合尼莫地平治疗老年慢性脑供血不足临床疗效及安全性。方法研究纳入63例老年慢性脑供血不足患者,均由医院2018年4月—2020年4月门诊收治,采取随机数字表法将其分为观察组与对照组,予以对照组患者(31例)尼莫地平治疗,予以观察组患者(32例)逐瘀通脉胶囊结合尼莫地平治疗,比较两组患者治疗效果、治疗前后中医症状(眩晕头痛、耳鸣耳聋、心悸多梦、面色少华、疲惫乏力、舌黯紫苔薄白等)积分变化、认知功能量表评分变化、经颅多普勒检测指标变化、血液流变学指标及血脂指标变化、血清炎症因子水平变化、不良反应。结果观察组患者治疗总有效率(96.88%,31/32)高于对照组(77.42%,24/31)(P<0.05);治疗前,两组患者眩晕头痛、耳鸣耳聋、心悸多梦、面色少华、疲惫乏力、舌黯紫苔薄白等中医症状积分、蒙特利尔认知评估量表评分(MoCA)、简易精神状态量表(MMSE)评分、收缩期血流速度(MCAVs)、搏动指数(PI)、平均血流速度(MCAVm)等经颅多普勒指标、血浆黏度、全血黏度及纤维蛋白原等血液流变学指标、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等血脂指标、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)及肿瘤坏死因子-α(TNF-α)等指标比较,P>0.05,治疗后各组患者眩晕头痛、耳鸣耳聋、心悸多梦、面色少华、疲惫乏力、舌黯紫苔薄白等中医症状积分、MoCA及MMSE评分、MCAVs、PI、MCAVm、血浆黏度、全血黏度及纤维蛋白原、TC、TG、LDL-C、HDL-C、IL-6、hs-CRP、TNF-α等指标均改善,观察组患者治疗后眩晕头痛、耳鸣耳聋、心悸多梦、面色少华、疲惫乏力、舌黯紫苔薄白等中医症状积分、MoCA及MMSE评分、MCAVs、PI、MCAVm、血浆黏度、全血黏度及纤维蛋白原、TC、TG、LDL-C、HDL-C、IL-6、hs-CRP、TNF-α等指标均优于对照组(P<0.05);Objective To explore the clinical efficacy and safety of Zhuyu Tongmai Capsule(逐瘀通脉胶囊) combined with nimodipine in the treatment of chronic cerebral insufficiency in the elderly. Methods In this study, 63 elderly patients with chronic brain blood insufficiency were included, all of whom were admitted to the outpatient department of our hospital from April 2018 to April 2020. They were divided into observation group and control group by random number table method. Patients in the control group(31 cases) were treated with nimodipine, and those in the observation group(32 cases) were treated with Zhuyu Tongmai Capsule combined with nimodipine. The results of the two groups were compared, the scores of TCM symptoms(dizziness, tinnitus and deafness, palpitation and dreams, less complexion, fatigue and fatigue, thin and white tongue purple coating), cognitive function scale score, changes of TCD, hemorheology and blood lipid, serum inflammatory factors and adverse reactions were compared. Results The total effective rate(96.88%,31/32) in the observation group was higher than that in the control group(77.42%,24/31)(P<0.05). Before treatment, TCM symptom scores, Montreal Cognitive Assessment Scale(MoCA), Mini Mental State Examination(MMSE), systolic blood flow velocity(MCAVs), pulsatility index(PI), mean blood flow velocity(MCAVm) and other TCD indexes, plasma viscosity, whole blood viscosity, fibrinogen and other hemorheological indexes, total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C) and other blood lipid indexes, interleukin-6(IL-6), high sensitivity C-reactive protein(hs-CRP) and tumor necrosis factor-α(TNF-α) were not significant(P<0.05). After treatment, TCM symptom scores, MOCA and MMSE scores, MCAVs, PI, MCAVm, plasma viscosity, whole blood viscosity, fibrinogen, TC, TG, LDL-C, HDL-C, IL-6, hs-CRP and TNF-α in the observation group were improved. The other indexes were better than those of the control group(P<0.05). Th

关 键 词：老年慢性脑供血不足 逐瘀通脉胶囊 尼莫地平 疗效 不良反应 

分 类 号：R277.743.31[医药卫生—中医学]