咖啡酸片联合传统免疫治疗干燥综合征血液系统损害的临床疗效  

Clinical efficacy of caffeic acid tablet combined with traditional immunotherapy in the treatment of blood system damage in Sjogren's syndrome

作　　者：孟德钎[1] 李永胜[1] 李鞠[1] 王凯[1] 张钟元 许益琳 MENG Deqian;LI Yongsheng;LI Ju;WANG Kai;ZHANG Zhongyuan;XU Yilin(Department of Immunology and Rheumatology,the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University,Jiangsu,Huai'an 223300,China;Department of Medical Oncology,the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University,Jiangsu,Huai'an 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院免疫风湿科,江苏淮安223300 [2]南京医科大学附属淮安第一医院肿瘤内科,江苏淮安223300

出　　处：《中国医药科学》2021年第19期192-195,共4页China Medicine And Pharmacy

基　　金：江苏省淮安市卫生健康科研项目(HAWJ201902)。

摘　　要：目的探讨咖啡酸片在原发性干燥综合征(pSS)血液系统损害治疗中的疗效及安全性。方法选取2018年10月至2019年10月在南京医科大学附属淮安第一医院住院和门诊确诊pSS有白细胞减少、血小板减少的患者72例,随机分为治疗组(n=36)和对照组(n=36),对照组仅口服小剂量醋酸泼尼松联合硫酸羟氯喹治疗,治疗组另予咖啡酸片口服治疗。对两组患者治疗前和治疗4周后的白细胞、血小板计数并进行比较,并观察两组患者出现并发症、不良反应情况。结果治疗组和对照组患者治疗前外周血白细胞计数比较,差异无统计学意义(P>0.05)。两组患者治疗4周后白细胞计数均高于治疗前,治疗组治疗4周后白细胞计数高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前外周血血小板计数比较,差异无统计学意义(P>0.05)。两组患者治疗4周后血小板计数高于治疗前,治疗组治疗4周后血小板计数高于对照组,差异有统计学意义(P<0.05)。结论咖啡酸片配合免疫治疗对pSS外周白细胞减少和血小板减少有较好的短期疗效,优于单用传统免疫治疗。Objective To investigate the efficacy and safety of caffeic acid tablet in the treatment of blood system damage in primary Sjogren's syndrome(pSS).Methods A total of 72 cases inpatients and outpatients with leukopenia and thrombocytopenia in the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University who were diagnosed with pSS from October 2018 to October 2019 and were randomly divided into the treatment group(n=36)and the control group(n=36).The control group was treated with only a small dose of prednisone acetate combined with hydroxychloroquine sulfate orally,while the treatment group was treated with caffeic acid tablet orally on the basis of the treatment of the control group.The white blood cell and platelet count before treatment and 4 weeks of treatment were analyzed and compared between the two groups.The complications and adverse reactions of patients in the two groups were observed.Results There was no statistically significant difference between the peripheral white blood cell count of patients in the treatment group and the control group before treatment(P>0.05).After treatment,the white blood cell count of patients in both groups after week 4 was higher than that before treatment,and the white blood cell count after week 4 in the treatment group was higher than that in the control group,with statistically significant differences(P<0.05).Before treatment,there was no statistically significant difference between the peripheral platelet counts in the two groups(P>0.05).After treatment,the platelet count of patients in both groups after week 4 was higher than that before treatment,and the platelet count after week 4 in the treatment group was higher than that in the control group,with statistically significant differences(P<0.05).Conclusion Caffeic acid tablet combined with immunotherapy had better short-term efficacy on peripheral leukopenia and thrombocytopenia in pSS than traditional immunotherapy alone.

关 键 词：原发性干燥综合征 咖啡酸片 白细胞减少 血小板减少 

分 类 号：R593.2[医药卫生—内科学]