辅助生殖技术助孕后子代哮喘发生风险的Meta分析  

Meta-analysis of the risk of asthma in the offspring after assisted reproductive technology

作　　者：王舒可 郑梅玲[1] Wang Shuke;Zheng Meiling(Department of Eugenics and Genetics,First Hospital of Shanxi Medical University,Taiyuan Shanxi 030000,P.R.China)

机构地区：[1]山西医科大学第一医院优生遗传室,山西太原030000

出　　处：《中国计划生育和妇产科》2021年第10期47-52,共6页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的系统评价辅助生殖技术(assisted reproductive technology,ART)与子代哮喘发生率的相关性。方法计算机检索Pub Med、EMbase、Cochrane library、中国生物医学文献数据库(CBM)、CNKI、维普和万方数据库。搜索ART与子代哮喘相关的观察性研究,检索时间从2000年1月至2020年7月,在进行提取资料和质量评价后,使用Rev Man 5.3软件和Stata 14.0软件进行数据分析。结果共纳入12篇高质量的观察性研究,共计3174605例子代进行Meta分析。与自然受孕(naturally conceived,NC)子代相比,ART子代哮喘发生率显著增加[OR=1.37,95%CI(1.11-1.70),P<0.05];剔除1篇异质性较大的研究后进行亚组分析,单胎子代中,ART组子代哮喘发生率风险明显高于NC组[OR=1.20,95%CI(1.10-1.32),P<0.05];受精方式亚组中,体外受精(in vitro fertilization,IVF)组与卵细胞胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)组的子代哮喘发生风险率均增加[OR=1.21,95%CI(1.10-1.32),P<0.05]vs[OR=1.42,95%CI(1.07-1.88),P<0.05],且ICSI组较IVF组对子代哮喘发生率的影响更显著;0~5岁子代与6~9岁ART子代哮喘发生风险分别较NC子代增加[OR=1.50,95%CI(1.10-2.04),P<0.05]vs[OR=1.23,95%CI(1.11-1.36),P<0.05]。结论现有证据表明,与NC子代相比,ART助孕可能会导致子代哮喘发病率的增加。Objective To investigate the correlation between assisted reproductive technology(ART)and the incidence of asthma in offspring.Methods PubMed,EMbase,Cochrane library,Wanfang Data,CNKI and VIP databases were searched to collect observational studies published related to asthma in offspring conceived by ART from January 2000 to July 2020.After data extraction and quality assessment,Meta-analysis was performed using RevMan 5.3 software and Stata 14.0 software.Results 12 high-quality observational studies with 3174605 cases were analyzed for Meta-analysis.The results showed that the incidence rate of child asthma in ART group was significantly higher compared with naturally conceived(NC)group[OR=1.37,95%CI(1.11-1.70),P<0.05].After excluding one study with large heterogeneity,the risk of child asthma of ART group was significantly higher than that of NC group only in singletons group[OR=1.20,95%CI(1.10-1.32),P<0.05].Compared with NC group,singletons in IVF group have the significantly higher risk of asthma[OR=1.21,95%CI(1.10-1.32),P<0.05].In the subgroup of fertilization methods,the risk of asthma in the offspring of the in vitro fertilization(IVF)group and intracytoplasmic sperm injection(ICSI)group increased[OR=1.21,95%CI(1.10-1.32),P<0.05]vs[OR=1.42,95%CI(1.07-1.88),P<0.05],and the ICSI group had a more significant impact on the incidence of asthma in the offspring than the IVF group;The risk of asthma in ART children from 0 to 5 years old and ART children from 6 to 9 years old was higher than that in NC children[OR=1.50,95%CI(1.10-2.04),P<0.05]vs[OR=1.23,95%CI(1.11-1.36),P<0.05].Conclusion ART was associated with significantly higher rate of child asthma compared with natural conception.

关 键 词：辅助生殖技术 体外受精 子代 哮喘 META分析 

分 类 号：R715.5[医药卫生—妇产科学]