新型2,5-取代-1,3,4-噻二唑衍生物的合成与杀菌活性  

Synthesis and Fungicidal Activities of 2,5-Disubstituted-1,3,4-thiadiazole Derivatives

作　　者：王威[1] 黄晓瑛[1] 王列平[1] 郑晓蕊[1] 刘康云[1] 王储备[2] 屈应莲 WANG Wei;HUANG Xiao-ying;WANG Lie-ping;ZHENG Xiao-rui;LIU Kang-yun;WANG Chu-bei;QU Ying-lian(State Key Laboratory of Fluorine&Nitrogen Chemicals,Xi’an Modern Chemistry Research Institute,Xi’an 710065,China;Institute of Energy and Fuel,Xinxiang University,Xinxiang 453000,China)

机构地区：[1]西安近代化学研究所氟氮化工资源高效开发与利用国家重点实验室,陕西西安710065 [2]新乡学院能源与燃料研究所,河南新乡453000

出　　处：《合成化学》2021年第10期850-855,共6页Chinese Journal of Synthetic Chemistry

基　　金：西安市科技计划项目(2020KJC0145)。

摘　　要：根据活性亚结构拼接原理,以2,2-二氟-1,3-苯并二噁茂为起始原料,合成了9个结构新颖的2,5-取代-1,3,4-噻二唑衍生物(I1~I9),其结构经^(1)H NMR,^(13)C NMR,^(19)F NMR,MS(EI)和元素分析表征,并对化合物的杀菌活性进行了初步测试。结果表明:在100 mg/L浓度下,化合物I-1和I-5对苹果树腐烂病菌(Valsa mali)的抑制活性超过92%,具有进一步研究的价值。Based on the fragment combination,nine novel 2,5-disubstituted-1,3,4-thiadiazole derivatives(I1~I9)were synthesized from benzodioxole.Their structures were characterized by ^(1)H NMR,^(13)C NMR,^(19)F NMR,MS(EI)and elemental analysis.Then the fungicides activities of I1~I9 against five fungi were evaluated at 100 mg/L.The target compounds I-1 and I-5 displayed more than 92%inhibiton effect against Valsa mali,which could be modified for further study.

关 键 词：1 3 4-噻二唑 2 2-二氟-1 3-苯并二噁茂 合成 杀菌活性 结构拼合 

分 类 号：O626[理学—有机化学]