PLLA-TMC微球增强磷酸钙骨水泥的制备与性能研究  

Preparation and Properties of Calcium Phosphate Cement Reinforced by PLLA-TMC Microspheres

作　　者：米霜 邢璐瑶 陈栋梁[1,2] 熊成东 鲁越[3] 李庆 MI Shuang;XING Lu-yao;CHEN Dong-liang;XIONG Cheng-dong;LU Yue;LI Qing(Chengdu Institute of Organic Chemistry,Chinese Academy of Science,Chengdu 610041,China;University of Chinese Academy of Science,Beijing 10049,China;School of Material Science and Engineering,Sichuan University of Science&Engineering,Zigong 643000,China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]中国科学院大学,北京100049 [3]四川轻化工大学材料科学与工程学院,四川自贡643000

出　　处：《合成化学》2021年第10期888-892,共5页Chinese Journal of Synthetic Chemistry

基　　金：四川轻化工大学人才引进项目(2019RC02)。

摘　　要：以左旋丙交酯(L-LA)和三亚甲基碳酸酯(TMC)为原料,辛酸亚锡为催化剂,采用本体聚合法制备了不同单体配比的二元无规共聚物(PLTMC64,PLTMC73和PLTMC82),其结构和性质经^(1)H NMR,FT-IR,GPC和DCS等表征。采用水包油法将3种二元PLLA-TMC共聚物制成平均直径约50μm的微球,以5 wt%含量加入到磷酸钙骨水泥中进行固化时间与力学性能测试。结果表明:添加PLTMC73微球为增强相时,骨水泥压缩强度增高到22 MPa左右,且压缩模量能达到1.5 GPa。SEM照片显示,骨水泥与微球之间有较好的亲和性。Random copolymers(PLTMC64,PLTMC73 and PLTMC82)with different monomer ratios were synthesized by bulk polymerization using L-lactide(L-LA)and trimethyl carbonate(TMC)as reaction monomers and stannous caprylate as catalyst.Its chemical structure was characterized by FT-IR and ^(1)H-NMR.The physical and chemical properties were characterized by GPC,DCS and contact Angle.Three kinds of PLLA-TMC copolymers were prepared into microspheres with an average diameter of about 50μm by Water/Oil method.The microspheres were added into calcium phosphate cement with the content of 5 wt%to test the curing time and mechanical properties.The results showed that when PLTMC73 microspheres were added as the reinforcing phase,the compressive strength of bone cement increased to 22 MPa,and the compressive modulus reached 1.5 GPa.It can be found that there was a good affinity between bone cement and microspheres from SEM images.

关 键 词：左旋丙交酯 三亚甲基碳酸酯 制备 微球占位 磷酸钙骨水泥 增强作用 

分 类 号：O62[理学—有机化学]