杂环手性辅助剂不对称合成方法综述——纪念有机立体化学名家Ernest L.Eliel敎授  

Review of Heterocyclic Chiral Adjuvant Asymmetric Synthesis Method——In Memory of Professor Ernest L.Eliel,A Master in Organic Stereochemistry

作　　者：何煦昌 HE Xu-chang(Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China)

机构地区：[1]中国科学院上海药物研究所,上海201203

出　　处：《合成化学》2021年第10期893-901,共9页Chinese Journal of Synthetic Chemistry

摘　　要：回顾了有机立体化学发展的历史,其间Eliel敎授主写的几本优良的立体化学教科书是适合时势和杰出的著作,特别是1962年出版的“碳化合物立体化学”影响众多的有机化学工作者。对Eliel教授发展的应用杂环手性辅助剂是不对称合成方法之一,对手性辅助剂N-苄基-4,4,7α-三甲基-trans-八氢-1,3-苯并氧氮杂环己烷中间体的制备和其应用,作了较详细的阐述。Eliel敎授杰出的科学成就和他在推广科学全球化贡献作了介绍。Long history of organic stereochemistry was briefly reminisced.A few textbooks of organic stereochemistry written mainly by Prof.Eliel,particularly“Stereochemistry of Carbon Compounds”published in 1962,were very timely and excellent works.Using heterocyclic chiral adjuvant,a method of asymmetric synthesis,was developed by Eliel.Preparation and applications of the chiral adjuvant,N-benzyl-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine intermediates,were discussed in detail.Eliel’s scientific contributions to stereochemistry and promoted global connectivity were simply presented.

关 键 词：有机立体化学 不对称合成 手性辅助剂 N-苄基-4 4 7α-三甲基-trans-八氢-1 3-苯并氧氮杂环己烷 Ernest L.Eliel 综述 

分 类 号：O621.9[理学—有机化学]