2,2-二溴-1-苯基乙烯在杂环合成中的应用研究进展  

Progress in Application of 2,2-Dibromo-1-phenylethylene in Heterocyclic Synthesis

作　　者：张文生 李焱[2] 周鸿燕[1] 左国强[1] 苏小莉[1] 刘改云[1] ZHANG Wen-sheng;LI YaN;ZHOU Hong-yan;ZUO Guo-qiang;SU Xiao-li;LIU Gai-yun(Department of Metallurgy and Chemical Engineering,Jiyuan Vocational and Technical College,Jiyuan 459000,China;Institute of Synthetic Technology,Jiaozuo Teachers College,Jiaozuo 454100,China)

机构地区：[1]济源职业技术学院冶金化工系,河南济源459000 [2]焦作师范高等专科学校合成技术研究所,河南焦作454100

出　　处：《化学试剂》2021年第11期1527-1535,共9页Chemical Reagents

基　　金：河南省科技攻关计划项目(212102310883);河南省教育厅自然科学重点研究计划项目(20B150014,21B150013);济源职业技术学院2020年重点科研课题项目(JZXY-2020-58)。

摘　　要：2,2-二溴-1-苯基乙烯是一类重要的有机合成中间体,广泛应用于合成吲哚、苯并呋喃、苯并噻吩、苯并吡喃、喹啉、异香豆素等稠杂环和芳基取代的杂环类化合物。在有关综述的基础上,主要对2013年后该领域的最新研究进展进行综述。该综述主要涉及两类反应:以2,2-二溴-1-苯基乙烯为原料,通过分子内反应构建吲哚、苯并呋喃、苯并噻吩和苯并硒吩类杂环化合物,以及在苯并呋喃类天然产物合成中的应用进展;基于2,2-二溴-1-苯基乙烯,通过分子间环化合成芳基取代噻吩、芳基取代三唑、呋喃和香豆素等杂环化合物。2,2-Dibromo-1-phenylethylene is an important intermediate in organic synthesis,which is widely applied in the synthesis of fused heterocycles,including indoles,benzofurans,benzothiophenes,benzopyrans,quinolines,isocoumarins and aryl substituted heterocyclic compounds.Based on the previous reviews,the latest research progress in the field since 2013 was covered.Two classes of reactions were involved:Construction of indoles,benzofurans,benzothiophenes and benzoselenophene derivatives based on 2,2-dibromo-1-phenylethylenes by intramolecular reaction,and the applications of 2,2-dibromo-1-phenylethylenes in the synthesis of benzofuran natural products;Synthesis of aryl-substituted thiophenes,aryl-substituted triazolse,furans and coumarins via intermolecular cyclization from 2,2-dibromo-1-phenylethylenes.

关 键 词：2 2-二溴-1-苯基乙烯 杂环 合成 分子内反应 环化 

分 类 号：O621.3[理学—有机化学]