钯催化脱氢制备苯并二氢■嗪酮类化合物研究  

Synthesis of Benzodihydrooxazinones via Palladium Catalyzed Dehydrogenation

作　　者：冀旋 胥加腾 刘仁华[1] JI Xuan;XU Jia-teng;LIU Ren-hua(School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]华东理工大学药学院,上海200237

出　　处：《化学试剂》2021年第11期1604-1610,共7页Chemical Reagents

摘　　要：针对现有合成苯并二氢■嗪酮的方法大多存在底物范围窄、需要化学计量的氧化剂、副产物多等问题,发展了一种Pd/C催化N-取代水杨酰胺脱氢环化合成苯并二氢■嗪酮类化合物的方法。方法在无氧化剂和氢接受体条件下,以较高产率获得苯并二氢■嗪酮类化合物,氢气为唯一副产物,反应体系简单、原子经济性高、环境友好,符合绿色化学发展的要求。Most of the existing methods for synthesizing benzodihydrooxazinones have problems such as a narrow substrate range,a stoichiometric amount of oxidant,and many by-products.A Pd/C-catalyzed N-substituted salicylamide dehydrocyclization method was developed to synthesize benzodihydrooxazinones.The method,without any oxidants and hydrogen acceptors,obtained benzodihydrooxazinones in a higher yield.Hydrogen was the only by-product.The reaction system has a simple reaction system,high atomic economy,environmental friendliness,and meets the requirements of green chemistry development.

关 键 词：苯并二氢■嗪酮 PD/C N-取代水杨酰胺 脱氢 原子经济性 

分 类 号：O626.4[理学—有机化学]