肺移植免疫学相关基础与临床研究进展  

Progress on basic and clinical research of immunology in lung transplantation

作　　者：肖漓 解立新 石炳毅 Xiao Li;Xie Lixin;Shi Bingyi(Institute of Respiratory and Critical Care Medicine,the 8th Medical Center of Chinese People’s Liberation Army General Hospital,Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory,Beijing 100091,China)

机构地区：[1]中国人民解放军总医院第八医学中心呼吸与危重症医学部研究所,北京市器官移植与免疫调节重点实验室,北京100091

出　　处：《器官移植》2021年第6期637-642,共6页Organ Transplantation

基　　金：国家自然科学基金(81571555)。

摘　　要：器官移植受者的生存质量与免疫状态密切相关。与其他实体器官移植相比,肺移植受者的长期预后较差,其涉及的免疫学机制更为复杂,既有共性又有特性。因此,深入了解同种异体肺移植免疫应答过程中的免疫学机制对于改善肺移植受者的长期生存尤为重要。本文从肺脏免疫细胞组成的独特性、肺移植术后排斥反应特点、肺移植病原体感染的早期预警和鉴别诊断以及肺移植相关并发症等方面进行探讨,总结同种异体肺移植涉及免疫学相关的临床诊断和基础研究进展,旨在阐述肺移植的免疫学特点,为临床提高肺移植受者的长期生存率以及移植物失功的防治水平等提供理论依据。The quality of life of organ transplant recipients is closely correlated with immune status.Compared with those undergoing other solid organ transplantation,the long-term prognosis of lung transplant recipients is worse.The underlying immune mechanism is complex with both similarities and characteristics.Therefore,in-depth understanding of the immune mechanism in the process of immune response of allogeneic lung transplantation plays a critical role in improving the long-term survival of the recipients.In this article,the unique composition of immune cells in the lung,the characteristics of rejection after lung transplantation,the early warning and differential diagnosis of pathogen infection in lung transplantation and postoperative complications after lung transplantation were investigated.Research progress on clinical diagnosis and basic studies related to immunology in allogeneic lung transplantation were summarized,aiming to elucidate the immunological characteristics of lung transplantation and provide theoretical basis for improving the longterm survival of lung transplant recipients and prevention and treatment of allograft dysfunction.

关 键 词：肺移植 移植免疫 免疫细胞 排斥反应 移植物失功 感染 阻塞性睡眠呼吸暂停综合征 外泌体 

分 类 号：R617[医药卫生—外科学] R392[医药卫生—临床医学]