间充质干细胞治疗缺血性胆道损伤的研究进展  

Research progress on mesenchymal stem cell in treatment of ischemic-type biliary lesion

作　　者：代鑫 程龙 王强[1] 骆助林 汪涛 Dai Xin;Cheng Long;Wang Qiang;Luo Zhulin;Wang Tao(North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院,四川南充637000 [2]中国人民解放军西部战区总医院普通外科中心

出　　处：《器官移植》2021年第6期748-753,共6页Organ Transplantation

基　　金：四川省青年科技基金项目(2016JQ0023)。

摘　　要：目前,缺血性胆道损伤(ITBL)的临床治疗仍以外科手术、内镜治疗等方法为主,具有治疗策略单一、治疗方法难度大和医疗费用高的缺点,亟需寻找一种新的治疗策略。间充质干细胞(MSC)具有高度的自我更新能力、多向分化潜能、低免疫原性及免疫调节作用等特性,已然成为再生医学中组织和器官修复的潜在种子细胞。近年来众多研究发现,MSC移植到ITBL动物模型后,不但可归巢到损伤区域,而且可通过抗凋亡、促血管新生等作用促进损伤胆道组织的修复,这表明MSC移植有望成为治疗ITBL的新策略。本文对MSC的生物学特性、MSC移植治疗ITBL的机制及其临床应用做一综述。At present,surgical and endoscopic interventions are mainly employed to treat ischemic-type biliary lesion(ITBL).Due to the disadvantages of single therapeutic strategy,high difficulty and expensive medical cost,it is urgent to identify a novel treatment option.Mesenchymal stem cell(MSC)has become potential seed cell for tissue and organ repair in regenerative medicine due to its high self-renewal capability,multi-directional differentiation potential,low immunogenicity and immunoregulatory effects,etc.Recent studies have demonstrated that MSC transplantation into ITBL animal models may not only home to the injured area,but also promote the repair of injured biliary tract tissues through anti-apoptotic and pro-angiogenic effect,which indicates that MSC transplantation is expected to become a new strategy for the treatment of ITBL.In this article,the biological characteristics of MSC,the mechanism and clinical application of MSC transplantation for ITBL were reviewed.

关 键 词：间充质干细胞(MSC) 人脐带间充质干细胞(hUC-MSC) 归巢 缺血性胆道损伤(ITBL) 良性胆道狭窄(BBS) 移植治疗 免疫调节 外泌体 

分 类 号：R617[医药卫生—外科学] R392.12[医药卫生—临床医学]