基于分子识别的细菌检测研究进展  

Advances in Bacteria Biosensing Based on Molecular Recognition

作　　者：张晓荣 陈岚岚 胡善文 ZHANG Xiaorong;CHEN Lanlan;HU Shanwen(Department of Health Inspection and Quarantine,School of Public Health,Fujian Medical University,Fuzhou 350122,China;College of Chemistry,Fuzhou University,Fuzhou 350108,China)

机构地区：[1]福建医科大学公共卫生学院卫生检验与检疫学系,福州350122 [2]福州大学化学学院,福州350108

出　　处：《高等学校化学学报》2021年第11期3468-3476,共9页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21804064,21804068)资助。

摘　　要：以抗体-抗原免疫识别、核酸碱基互补配对识别以及核酸适体-配体识别这3种分子识别方式分类,综述了近几年基于分子识别的细菌检测研究工作进展,总结了细菌检测相关研究存在的一些挑战,并展望了该领域的发展前景.Bacteria widely exist in the natural environment and are closely related to human health.The identification and detection of bacteria are of great significance for public health and medical health.Recently,more attention has been attracted in molecular recognition-based bacteria biosensing with high specificity and sensitivity.Herein,recent progresses of bacterial detection based on molecular recognition are reviewed.Molecular recognition methods are classified into three kinds of interactions:antibody-antigen immune interaction,nucleic acid recognition based on Watson-Crick base-pairing,and aptamer-ligand interaction.Finally,the existing bottlenecks of bacterial detection related research are summarized,and the potential of this field is inspiring.

关 键 词：分子识别 细菌检测 核酸探针 免疫识别 核酸适体 

分 类 号：O652[理学—分析化学] R185[理学—化学]