骨转换生化标志物临床应用指南  

Guidelines for clinical application of bone turnover biomarkers

作　　者：中华医学会骨质疏松和骨矿盐疾病分会 李梅 夏维波 章振林[3] 谢忠建 刘建民[5] 徐又佳[6] 侯建明[7] 陈德才 袁凌青 岳华 王鸥[10] 姜艳[10] 盛志峰 张浩 王覃 无;Li Mei;Xia Weibo;Zhang Zherdin(Chinese Society of Osteoporosis and Bone Mineral Research,Chinese Medical Association;Department of Endocrinology,Key Laboratory of Endocrinology of National Health Commission,Peking Union Medical College Hospital,Chinese Academy of Medical Science,Beijing 100730,China;Shanghai Clinical Research Center of Bone Diseases,Department of Osteoporosis and Bone Diseases,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China)

机构地区：[1]不详 [2]中国医学科学院北京协和医学院北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,北京100730 [3]上海交通大学附属第六人民医院骨质疏松和骨病专科,上海市骨疾病临床研究中心,200233 [4]中南大学湘雅二医院 [5]上海交通大学医学院附属瑞金医院 [6]苏州大学附二院 [7]福建省立医院 [8]四川大学华西医院 [9]上海交通大学附属第六人民医院 [10]北京协和医院

出　　处：《中华内分泌代谢杂志》2021年第10期863-874,共12页Chinese Journal of Endocrinology and Metabolism

基　　金：国家重点研发计划项目(2018YFA0800801);上海申康医院发展中心临床科技创新项目(SHDC12018120)。

摘　　要：骨转换对于防止骨骼疲劳损伤和维持机体矿物质平衡至关重要,骨转换失衡是多种骨骼疾病的关键病理生理机制。骨转换生化标志物(bone turnover markers,BTMs)是骨转换过程中产生的代谢产物或酶类,本指南介绍BTMs的测量方法、正常值及其在多种骨骼疾病的诊断与鉴别诊断、骨折风险预测、药物疗效评价等方面的重要作用。Bone turnover plays important roles in preventing bone impairment and maintaining bone mineral balance.Bone turnover imbalance is the key pathophysiological mechanism of a variety of bone disorders.Bone turnover biomarkers(BTMs)include metabolites or enzymes produced in the process of bone turnover.This guide presents the measurement methods and normal ranges of BTMs,and its important values in the diagnosis and differential diagnosis of multiple bone diseases,prediction of bone fracture risk,and evaluation of the efficacy of anti-osteoporotic medicines.

关 键 词：骨转换 骨转换生化标志物 骨质疏松症 

分 类 号：R68[医药卫生—骨科学]