针刺联合中药对肥胖型多囊卵巢综合征患者肠道菌群、糖脂代谢及炎症因子水平的影响  

Effect of acupuncture combined with traditional Chinese medicine on intestinal flora,glycolipid metabolism and inflammatory factor levels in patients with obese polycystic ovary syndrome

作　　者：李东海 李永攀 王雪 LI Dong-hai;LI Yong-pan;WANG Xue(Department of Traditional Chinese Medicine,Xuancheng People's Hospital,Xuancheng 242000;Department of Traditional Chinese Medicine,Outpatient Department of National Medical Hall,Anhui University of traditional Chinese Medicine,Hefei 231000;Department of Rehabilitation,Xuancheng Orthopedic Hospital,Xuancheng 242000,Anhui,China)

机构地区：[1]宣城市人民医院中医科,安徽宣城242000 [2]安徽中医药大学国医堂门诊部中医内科,安徽合肥231000 [3]宣城市骨科医院康复科,安徽宣城242000

出　　处：《川北医学院学报》2021年第10期1280-1285,共6页Journal of North Sichuan Medical College

基　　金：国家自然科学基金(81802586)。

摘　　要：目的:探讨针刺联合治肾化痰中药对肥胖型多囊卵巢综合征(PCOS)患者肠道菌群、糖脂代谢及炎症因子水平的影响。方法:选取100例肥胖型PCOS患者为研究对象,按照治疗方式不同分为观察组和对照组,每组各50例。对照组口服炔雌醇环丙孕酮片治疗,观察组在对照组基础上使用治肾化痰的中药联合针刺治疗。比较两组患者治疗前后糖脂代谢、炎症因子水平、肠道菌群数、肠道屏障功能指标的差异,分析肠道菌群与糖脂代谢、炎症因子及肠道屏障功能的相关性。结果:治疗前,两组肠道菌群、肠道屏障功能指标、糖脂代谢、炎症因子水平比较,差异无统计学意义(P>0.05)。治疗后,观察组糖代谢指标空腹胰岛素(FINS)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)水平、脂代谢指标总胆固醇高(TC)、甘油三脂(TG)水平、肠杆菌与肠球菌菌群数、肠道屏障功能指标D-乳酸和二胺氧化酶(DAO)水平、白细胞介素-6(IL-6)、C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)较对照组低(P<0.05),高密度脂蛋白(HDL-C)水平、乳杆菌和双歧杆菌的菌群数较对照升高(P<0.05);肠杆菌、肠球菌与肠道屏障功能、糖代谢、炎症因子及TC、TG呈正相关(P<0.05),与HDL-C呈负相关(P<0.05);乳杆菌、双歧杆菌与肠道屏障功能、糖代谢、炎症因子及TC、TG呈负相关(P<0.05),与HDL-C呈正相关(P<0.05)。结论:针刺联合中药对肥胖型PCOS患者有良好的治疗作用,可有效改善患者肠道菌群、肠道屏障功能、糖脂代谢和炎症因子水平。Objective:To observe the effect of acupuncture combined with traditional Chinese medicine on intestinal flora,glycolipid metabolism and inflammatory factor levels in patients with obese polycystic ovary syndrome.Methods:100 patients with obese polycystic ovary syndrome were divided into observation group(n=50)and control group(n=50)according to different treatment methods.The Ethinylestradiol and Cyproterone Acetate Tablets were treated by a control group,and on the basis of the control group,treatment of Chinese medicine combined with acupuncture treatment were used to the observation group.The differences of sugar metabolism,blood lipid metabolism,inflammatory factor level,intestinal fungus group,and intestinal barrier function indicators between the two groups were compared before and after treatment,and the correlation betwen intestinal flora and intestinal barrier function,glycolipid metabolism,inflammatory factor level were analyzed.Results:Before treatment,there were no significant differences in the treatment of pre-intestinal flora,intestinal barrier function indicator,glycid metabolism,and inflammatory factors between the two groups(P>0.05).After treatment,the glucose metabolism indexes fasting insulin(FINS),fasting blood glucose(FPG),insulin resistance index(HOMA-IR),lipid metabolism indexes total cholesterol(TC),triglyceride(TG),the number of Enterobacteriaceae and enterococci,the levels of intestinal barrier function indexes D-lactic acid and diamine oxidase(DAO),inflammatory factor interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05),the levels of high density lipoprotein(HDL-C)and the number of bacteria in Lactobacillus and Bifidobacteria in the observation group were higher than those of the control group(P<0.05).Enterobacter and Enterococcus were positively correlated with intestinal barrier function,sugar metabolism,inflammatory factor,TC and TG(P<0.05),and negatively correlated with HDL-C(P<0.0

关 键 词：肥胖型多囊卵巢综合征 针刺 治肾化痰中药 肠道菌群 糖脂代谢 炎症因子 

分 类 号：R271.9[医药卫生—中西医结合]