西尼罗河病毒感染与免疫机制研究进展  

Overview of infection and immune mechanisms of West Nile virus

作　　者：孙静 何展 蔡畅 卫芳芳 程昌勇 宋厚辉 SUN Jing;HE Zhan;CAI Chang;WEI Fangfang;CHENG Changyong;SONG Houhui(Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province,China-Australia Animal Health Big Data Analysis Joint Laboratory,College of Animal Science and Technology/College of Veterinary Medicine,Zhejiang A&F University,Hangzhou 311300,China)

机构地区：[1]浙江农林大学动物科技学院/动物医学院浙江省畜禽绿色生态健康养殖应用技术研究重点实验室中澳动物健康大数据分析联合实验室,浙江杭州311300

出　　处：《中国兽医学报》2021年第10期2059-2063,共5页Chinese Journal of Veterinary Science

基　　金：国家重点研发计划专项“边境地区外来动物疫病阻断及防控体系研究”资助项目(2017YFD0501800)。

摘　　要：西尼罗河病毒(West Nile virus,WNV)是一种在世界范围内流行的嗜神经虫媒病毒,鸟类、马等多种动物和人均易感,蚊虫和鸟类是该病毒的主要传播媒介。WNV感染人引起以亚临床症状为主的西尼罗河热(West Nile fever,WNF),以典型的西尼罗河脑炎以及神经系统疾病为主要特征,严重可致死亡。研究显示,WNV感染在全球范围内呈逐步扩大趋势,对全世界人类公共卫生构成了重大威胁。WNV的持续蔓延以及缺乏有效防治感染的疗法和疫苗,迫切需要揭示WNV感染机制,从而为有效防控该疾病提供理论根据。现主要对近年来有关WNV感染以及宿主病毒互作免疫机制的研究进展进行综述。West Nile virus(WNV)is an important neurotropic arbovirus that can infect birds,horses,and humans,causing the West Nile fever(WNF).Mosquitoes and birds are the main vectors of the virus.WNV infection of humans causes subclinical WNF,which is characterized by typical West Nile encephalitis and neurological symptoms,and even death.WNV infection has become widely prevalent and poses a significant public health risk globally.With the continuous spreading of WNV and the lack of effective treatments and vaccines to prevent infection,it has become more and more urgent to reveal the molecular mechanisms of WNV infection to provide the theoretical basis for effective prevention and control of this disease.Here,we provide an overview of the updated research progress on WNV infection and immune mechanism of host-virus interaction.

关 键 词：西尼罗河病毒 免疫机制 公共卫生 

分 类 号：S852.65[农业科学—基础兽医学] R535[农业科学—兽医学]