间充质干细胞治疗动物肾损伤研究进展  

Progress in treatment of animal kidney injury with mesenchymal stem cells

作　　者：何文来 李巴仑 张慧敏 刘蕴蝶 彭莎[1] HE Wenlai;LI Balun;ZHANG Huimin;LIU Yundie;PENG Sha(Shaanxi Centre of Stem Cells Engineering&Technology,College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi 712100,China)

机构地区：[1]西北农林科技大学动物医学院陕西省干细胞工程技术研究中心,陕西杨凌712100

出　　处：《中国兽医学报》2021年第10期2076-2084,共9页Chinese Journal of Veterinary Science

基　　金：陕西省重点研发计划资助项目(2019NY-091)。

摘　　要：肾损伤是一种临床中较为常见的疾病,具有高发病率和高病死率的特点,可由多种原因引起且发病率随动物年龄的增长而增长。近来年,随着干细胞治疗研究的深入,以间充质干细胞(mesenchymal stem cells,MSCs)为代表的干细胞治疗肾损伤的报道不断增多。此外,各种有效策略及无细胞治疗技术的开发也进一步推进了MSCs治疗肾损伤的发展。现总结近年来关于MSCs治疗肾损伤的研究进展,以期为MSCs治疗肾损伤的进一步研究和临床应用提供一定的理论依据和技术指导。Kidney injury is a common disease characterized by high morbidity and mortality in clinic,which can be caused by many reasons and the incidence increases with the animal age.Recently,with the development of stem cell therapy research,mesenchymal stem cells(MSCs)-based therapy in kidney injury developed gradually.In addition,the development of various effective strategies and cell-free therapy has further promoted the development of MSCs-based therapy in kidney injury.This review aims to summarize the progress of MSCs transplantation for the treatment of kidney injury,which will provide a theoretical basis and technical guidance for further research and clinical application.

关 键 词：肾损伤 间充质干细胞 猫 犬 

分 类 号：S856.59[农业科学—临床兽医学] S857.17[农业科学—兽医学]