静脉活性药物在下肢慢性静脉疾病治疗中的应用  

Application of venoactive drugs in chronic venous diseases of lower limbs

作　　者：黄佃[1] 李晓强 HUANG Dian;LI Xiao-qiang(Department of Vascular Surgery,the Affiliated Hospital of Nanjing University School,Nanjing Drum Tower Hospital,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院血管外科,南京210008

出　　处：《临床药物治疗杂志》2021年第10期1-7,共7页Clinical Medication Journal

摘　　要：慢性静脉疾病(CVD)是一种常见的血管疾病,是因下肢静脉结构或功能异常使静脉血回流不畅或倒流、远端静脉压力过高导致的一系列症状和体征。CVD病因复杂,最常见病因是由静脉瓣膜功能不全引起血液反流导致的静脉高压。炎症在疾病进展中起重要作用。目前应用的静脉活性药物,可改善静脉张力和收缩力、减轻水肿和炎症、改善微循环和静脉溃疡愈合,并获得了大量临床研究的证实。本综述从作用机制、临床获益和指南地位上对目前可用的静脉活性药物进行评估。Chronic venous disease(CVD)is a common vascular disease.It is a series of symptoms and signs caused by high distal venous pressure,and poor venous blood refluxing or flowing backwards resulted from abnormal venous structure or function of lower limbs.The etiology of CVD is complicated,and the most common etiology of CVD is venous hypertension resulted from blood regurgitation due to venous valve insufficiency.Inflammation plays an important role in the progression of CVD.Currently available intravenous active drugs could improve venous tension and contractility,reduce edema and inflammation,perfect microcirculation and venous ulcer healing,and have been confirmed by a large number of clinical studies.This review aimed to evaluate currently available intravenous active agents in terms of mechanism of action,clinical benefit,and guideline status.

关 键 词：慢性静脉疾病 静脉活性药物 作用机制 

分 类 号：R972.4[医药卫生—药品] R543.6[医药卫生—药学]