丙戊酸盐联合团体认知行为疗法对双相情感障碍患者的炎症因子水平及生活质量的影响  

Effects of Valproate combined with group cognitive behavioral therapy on inflammatory factors levels and quality of life in patients with bipolar disorder

作　　者：张庆辉 艾立英 陈伟[1] 袁媛[1] 王璐 杨桂娟 杨海东[2] ZHANG Qing-hui;AI Li-ying;CHEN Wei;YUAN Yuan;WANG Lu;YANG Gui-juan;YANG Hai-dong(Department of Psychiatry,Chongqing Spiritual Health Center Geleshan Campus,Chongqing 400036,China;Department of Psychiatry,Lianyungang Fourth People's Hospital,Jiangsu Lianyungang,222000,China)

机构地区：[1]重庆市精神卫生中心歌乐山院区精神科,重庆400036 [2]连云港市第四人民医院精神科,江苏连云港222000

出　　处：《临床药物治疗杂志》2021年第10期71-75,共5页Clinical Medication Journal

摘　　要：目的探讨丙戊酸盐联合团体认知行为疗法(G-CBT)对双相情感障碍患者炎症因子水平及生活质量的影响。方法将2017年6月至2019年6月在重庆市精神卫生中心歌乐山院区诊治的146例双相情感障碍患者分为观察组72例与对照组74例,两组完成研究的最终人数均为64例。对照组给予丙戊酸盐治疗,观察组给予丙戊酸盐联合G-CBT治疗。8周后比较两组治疗效果,采用酶联免疫吸附法测定白细胞介素1β(IL-1β)、白细胞介素2(IL-2)、肿瘤坏死因子α(TNF-α)炎性因子水平变化,采用生活质量简表(SF-36)评价研究对象的生活质量。结果观察组治疗总有效率为90.6%,对照组为76.6%,差异有统计学意义(P<0.05)。治疗前两组患者IL-1β、IL-2和TNF-α水平差异无统计学意义(P>0.05),治疗后观察组患者的IL-1β、TNF-α指标水平显著低于对照组(P<0.05),IL-2指标水平两组间差异无统计学意义(P>0.05)。治疗前两组间SF-36量表8个维度评分差异无统计学意义(P>0.05),治疗后除躯体疼痛维度外,观察组各维度评分均显著高于对照组(P<0.05)。结论丙戊酸盐联合G-CBT治疗双相情感障碍治疗效果良好,可有效提高患者的生活质量,联合治疗后患者的IL-1β、TNF-α炎性因子的表达明显下降。Objective This study was designed to investigate the effect of Valproate combined with group cognitive behavioral therapy(G-CBT)on the inflammatory factors levels of and quality of life in patients with bipolar disorder.Methods A total of 146 patients with bipolar disorder diagnosed and treated in Geleshan Campus of Chongqing Mental Health Center from June 2017 to June 2019 were recruited as participants,and they were divided into treatment group(n=72)and control group(n=74),and 64 participants in each group completed this research.The patients in control group were treated with magnesium valproate,and those in treatment group were given magnesium Valproate combined with group-congnitive behavioral therapy(G-CBT).After 8 weeks,the treatment effects of the two groups were compared.The levels of interleukin-1β,IL-1β,intorleukin-2,IL-2,and tumor necrosis factor-α,TNF-αinflammatory factors were measured by enzyme-linked immunosorbent assay,and the quality of life of the study subjects was evaluated using the quality of life summary table(SF-36).Results The total effective rates of treatment group and control group were 90.6%and 76.6%respectively with statistically significant difference(P<0.05).The levels of IL-1β,IL-2 and,TNF-α in both groups before treatment were not statistically significant(P>0.05).After treatment,the levels of inflammatory factors in the two groups decreased significantly.The levels of IL-1β and TNF-α in treatment group were significantly lower than those in the control group(P<0.05),but the level of IL-2 was not statistically different between the two groups(P>0.05).There was no statistically significant difference in the scores of the eight dimensions of the SF-36 scale before treatment(P>0.05).Except for the bodily pain dimension,each dimension including physical function,role limitations due to physical health,general health,vitality,social function,role limitations due to emotional problems,and mental health of the treatment group scores were significantly higher than those in the c

关 键 词：双相情感障碍 团体认知行为疗法 炎性因子 丙戊酸盐 

分 类 号：R971.4[医药卫生—药品] R917[医药卫生—药学]