雾化吸入干扰素α2b注射液治疗小儿呼吸道合胞病毒肺炎对其炎症因子水平的影响  

Evaluation of the effect of nebulized inhalation of interferonα2b injection on the level of inflammatory factors in the treatment of children with respiratory syncytial virus pneumonia

作　　者：姜悦 朱雯 刘倩[1] JIANG Yue;ZHU Wen;LIU Qian(Department of Pharmacy,Tianjin Children’s Hospital,Tianjin 300074,China)

机构地区：[1]天津市儿童医院药剂科,天津300074

出　　处：《上海医药》2021年第21期43-45,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探析小儿呼吸道合胞病毒肺炎治疗中干扰素α2b注射液雾化吸入对患儿炎症因子水平的影响。方法:应用双盲法将98例小儿呼吸道合胞病毒肺炎患儿进行分组并予以不同的治疗方案,对实验组和对照组的治疗效果和肺功能指标差异进行比较。结果:实验组的住院时间、症状消失时间和病毒核酸转阴时间更短,FVC、FEV1和PEF水平均较高,IL-6、IL-10和TNF-α水平则均较低,且实验组的治疗有效率也要高于对照组(P<0.05)。结论:干扰素α2b注射液雾化吸入方案对于患儿病情的缓解有着重要意义,临床应用价值较高。Objective:To analyze the effect of aerosol inhalation of interferonα2b injection on the levels of inflammatory factors in the treatment of children with respiratory syncytial virus pneumonia.Methods:Ninety-eight cases of children with respiratory syncytial virus pneumonia were divided into groups by a double-blind method,to which different treatment schemes were given.The treatment effect and lung function index were compared between the two groups.Results:The times for hospital stay,symptom disappearance and viral nucleic acid negative were shorter,FVC,FEV1 and PEF levels and the effective rate of treatment were higher and IL-6,IL-10 and TNF-αlevels were lower in the experimental group than the control group(P<0.05).Conclusion:The aerosol inhalation scheme of interferonα2b injection is of great significance for the alleviation of children’s condition and has high clinical application value.

关 键 词：雾化吸入 干扰素α2b注射液 小儿呼吸道合胞病毒肺炎 炎症因子水平 

分 类 号：R978.7[医药卫生—药品] R725.6[医药卫生—药学]