新型邻胺基苯甲酰胺类杀虫剂的创制研究  

Discovery of Novel o-Aminobenzamides as Insecticides

作　　者：柳爱平 任叶果 李建明 龙楚云 蒋彪 刘兴平 罗先福 吴明峰 王燕 李敏 黄路 黄至畅 陈明 杜升华 欧晓明 刘卫东 LIU Ai-ping;REN Ye-guo;LI Jian-ming;LONG Chu-yun;JIANG Biao;LIU Xing-ping;LUO Xian-fu;WU Ming-feng;WANG Yan;LI Min;HUANG Lu;HUANG Zhi-chang;CHEN Ming;DU Sheng-hua;OU Xiao-ming;LIU Wei-dong(National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha 410014,China;Hunan Province Key Laboratory for Agrochemicals,Changsha 410014,China;HRICI Test Co.Ltd.,Changsha 410014,China;Hunan Haili Chemical Industry Co.,Ltd.,Changsha 410007,China)

机构地区：[1]湖南化工研究院有限公司,国家农药创制工程技术研究中心,湖南长沙410014 [2]农用化学品湖南省重点实验室,长沙410014 [3]湖南化研院检测技术有限公司,湖南长沙410014 [4]湖南海利化工股份有限公司,湖南长沙410007

出　　处：《精细化工中间体》2021年第5期10-13,共4页Fine Chemical Intermediates

基　　金：国家自然科学基金项目(22177033);湖南省企业科技创新创业团队项目(海利新材料科技创新创业团队);湖南省重点研发计划项目(2022NK2053)。

摘　　要：自主设计、合成了系列新型邻胺基苯甲酰胺类化合物,并对其进行了杀虫活性、安全性、毒性、工艺、制剂、温室和/或田间防治效果等研究,获得了Ia、Ib和Ic等系列自主知识产权的高杀虫活性化合物。结果表明化合物Ic等对咀嚼口器害虫如粘虫和小菜蛾等的活性较邻胺基苯甲酰胺类杀虫剂氯虫苯甲酰胺水平相当或更胜一筹,对刺吸口器害虫如蚜虫等的活性远优于氯虫苯甲酰胺及溴氰虫酰胺。田间药效试验进一步证实,Ic等对咀嚼口器害虫如水稻二化螟、稻纵卷叶螟、甜菜夜蛾等的防治效果相当于或优于氯虫苯甲酰胺,对刺吸口器害虫如蚜虫等的防治效果优于溴氰虫酰胺。新型邻胺基苯甲酰胺类化合物Ic等可作为候选杀虫剂进一步研究开发。A series of new o-aminobenzamides were designed and synthesized independently.Their insecticidal activity,safety,toxicity,preparation,greenhouse and/or field efficacy were studied,a series of high insecticidal activity compounds Ia,Ib and Ic with independent intellectual property rights was obtained.The results showed that the activity of Ic against chewing mouthparts pests such as Mythimna separata and Plutella xylostellawas better than that of Chlorantraniliprole,or at the same level,the activity of Ic against the piercing-sucking mouthparts pests such as aphids was much higher than that of Chlorantraniliprole,and better than that of Cyantraniliprole.The results of field tests confirmed that the efficacy of Icagainst chewing mouth pests including Chilo suppressalis(Walker)and Cnaphalocrocis medinalis Guenee,Spodoptera exigua Hiibner was better than or equivalent to that of Chlorantraniliprole,and the efficacy of Ic against the piercing-sucking mouthparts pests such as aphids was better than or equivalent to that of Cyantraniliprole.The new o-aminobenzamide compound Ic can be used as candidate insecticides for further research and development.

关 键 词：邻胺基苯甲酰胺类化合物 杀虫剂 创制 氯虫苯甲酰胺 

分 类 号：S482.3[农业科学—农药学]