肿瘤靶向Pt‑Cu基纳米平台用于近红外二区光声成像引导的光热治疗  

Tumor-Targeted Pt-Cu Nanoplatform for Photothermal Therapy Guided by the Second Near-Infrared Window Photoacoustic Imaging

作　　者：郑子良[1] 曲波涛 杨晓荣 刘玲[1] 张瑞平[1] ZHENG Zi-Liang;QU Bo-Tao;YANG Xiao-Rong;LIU Ling;ZHANG Rui-Ping(Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Taiyuan 030032,China)

机构地区：[1]山西医科大学第三医院,山西白求恩医院,山西医学科学院,太原030032

出　　处：《无机化学学报》2021年第11期1991-2001,共11页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.81571747,81771907);山西省面上青年基金(No.201901D211343)资助。

摘　　要：基于层层(LBL)自组装技术,在Pt-Cu纳米合金表面依次包覆带正电的聚赖氨酸(PLL)和带负电的透明质酸(HA),成功构筑Pt-Cu@PLL@HA纳米平台。HA不仅延长了纳米平台血液循环时间,还可实现肿瘤主动靶向作用,提升肿瘤部位富集效果。在肿瘤区域透明质酸酶(HAase)作用下HA快速降解,释放Pt-Cu@PLL(+)颗粒,有利于肿瘤细胞特异性摄取。基于Pt-Cu合金良好的近红外二区(NIR-Ⅱ)吸收性能,实现了NIR-Ⅱ光声成像引导的NIR-Ⅱ光热高效抗肿瘤效果。A nanoplatform Pt-Cu@PLL@HA based on Pt-Cu nano-alloys encapsulated in the positively charged polylysine(PLL)and negatively charged hyaluronic acid(HA)was constructed via layer-by-layer(LBL)self-assem-bly technology.HA not only prolonged the blood circulation time of Pt-Cu@PLL@HA,but also realized the active tu-mor targeting and enhanced its high accumulation in tumor region.After fast HA degradation in response to hyal-uronidase(HAase)in the tumor microenvironment,the site-specific exposure of Pt-Cu@PLL(+)was conducive to the uptake of tumor cells.Owing to the strong NIR-Ⅱ(the second near-infrared window)absorption capability of Pt-Cu alloy,the effective photothermal tumor ablation could be realized by the precise guidance of NIR-Ⅱphotoacoustic imaging.

关 键 词：近红外二区 光热治疗 光声成像 Pt-Cu合金 层层自组装 

分 类 号：TQ139.2[化学工程—无机化工] O614.826[理学—无机化学]