微流控芯片技术在抗深部真菌感染药物筛选中的研究进展  

Research progress of microfluidics in drug screening against deep fungal infection

作　　者：张晓莹 朱英霞(综述) 孙慎侠(审校)[1] ZHANG Xiao-ying;ZHU Ying-xia;SUN Shen-xia(The Medical College of Dalian University,Dalian 116622,Liaoning,CHINA)

机构地区：[1]大连大学医学院,辽宁大连116622

出　　处：《海南医学》2021年第21期2811-2814,共4页Hainan Medical Journal

基　　金：2020年国家级大学生创新创业训练计划项目(编号:202011258018)。

摘　　要：真菌感染尤其是深部真菌感染是造成免疫力低下患者发病和死亡的主要原因之一。现有抗真菌药物的抗菌谱、抗菌效果等难以满足临床需要;真菌耐药性日益严重。建立一种有效的评估抗深部真菌药物活性的筛选方法对于推动抗深部真菌药物的开发利用具有重要意义。近年来微流控芯片技术逐渐成为药物筛选的有力工具。因此,本文就微流控芯片技术在抗深部真菌感染药物筛选中的研究进展及应用前景做一综述。Fungal infections,especially deep fungal infections,were strongly associated with the significant morbidity and mortality of patients with immunodeficiency.The antifungal spectrum and antifungal effect of antibiotics were difficult to meet the clinical needs.The fungal resistance was becoming increasingly serious.It was greatly significant to establish an effective screening method to evaluate the activity of antifungal drugs for promoting the development and utilization of antifungal drugs.In recent years,microfluidic chip technology has gradually become a powerful tool for drug screening.Therefore,this paper summaries the progress and application prospect of microfluidics in the screening of antifungal drugs.

关 键 词：深部真菌 抗真菌药物 药物筛选 微流控技术 研究进展 

分 类 号：R379[医药卫生—病原生物学]