脑脊液β2MG、CRP及CSF-NSE对新生儿化脓性脑膜炎的诊断价值  

The diagnostic value of cerebrospinal fluidβ2MG,CRP and CSF-NSE for neonatal purulent meningitis

作　　者：杨夏 刘金凤 卢国增 YANG Xia;LIU Jinfeng;LU Guozeng(Department of Neonatal Medicine,Xuzhou Children's Hospital,Xuzhou,Jiangsu,China,221006)

机构地区：[1]徐州市儿童医院新生儿内科,江苏徐州221006

出　　处：《分子诊断与治疗杂志》2021年第10期1587-1590,共4页Journal of Molecular Diagnostics and Therapy

基　　金：江苏省卫生健康委科研项目(LGY2018048)。

摘　　要：目的分析脑脊液β2微球蛋白(β2MG)、C反应蛋白(CRP)及脑脊液神经元特异性烯醇化酶(CSF-NSE)对新生儿化脓性脑膜炎的诊断价值。方法选取徐州市儿童医院新生儿内科2017年3月至2021年6月收治的105例新生儿为研究对象,依据病原学检查结果,根据是否发生化脓性脑膜炎分为发生组(73例)和未发生组(32例)。将患者检测后的脑脊液β2MG、CRP及CSF-NSE指标进行比较,采集不同感染类型,不同病情程度的数据,并采用受试者工作特征曲线(ROC)评估脑脊液β2MG、CRP及CSF-NSE对新生儿化脓性脑膜炎的诊断价值。结果比较两组患儿β2MG、CRP及CSF-NSE的检测,发生组差异显著高于未发生组,差异有统计学意义(P<0.05)。比较革兰阳性菌和革兰阴性菌β2MG、CRP及CSF-NSE的检测情况,G-患儿各项指标显著低于G+,比较差异有统计学意义(P<0.05)。比较轻度,中度,重度情况下β2MG、CRP及CSF-NSE的检测情况,重度患儿均高于轻中度患儿,差异有统计学意义(P<0.05),中度患儿均高于轻度患儿,差异有统计学意义(P<0.05)。ROC曲线分析显示,β2MG、CRP、CSF-NSE及三项联合指标诊断新生儿化脓性脑膜炎的ROC曲线下面积AUC分别为0.882、0.840、0.787、0.890,三项联合AUC均明显高于各单项指标(P<0.05)。结论脑脊液β2MG、CRP及CSF-NSE在新生儿化脓性脑膜炎中显著升高,三者联合可提高诊断新生儿化脓性脑膜炎的敏感度,准确性。Objective To analyze the diagnostic value of cerebrospinal fluidβ2 microglobulin(β2MG),C-reactive protein(CRP)and cerebrospinal fluid neuron-specific enolase(CSF-NSE)for neonatal purulent meningitis.Methods A total of 105 neonates admitted to the Department of Neonatal Medicine in Xuzhou Children.s Hospital from March 2017 to June 2021 were selected as the research objects.Based on the results of pathogenic examinations and whether purulent meningitis occurred,they were divided into an occurrence group(73 cases)and a non-occurring group(32 cases).The cerebrospinal fluidβ2MG,CRP and CSF-NSE indicators were compared,data of different infection types and different disease levels were collected,and the receiver operating characteristic curve(ROC)was used to evaluate the diagnostic value of cerebrospinal fluidβ2MG,CRP and CSF-NSE for the newborn purulent meningitis.Results Comparing the detection ofβ2MG,CRP and CSF-NSE between the two groups of children,the difference between the occurrence group was significantly higher than that of the non-occurrence group,and the difference was statistically significant(P<0.05).Comparing the detection conditions of gram-positive bacteria and gram-negative bacteria,the indicators ofβ2MG,CRP and CSF-NSE in children with G-were significantly lower than those with G+,and the difference was statistically significant(P<0.05).Comparing the detection ofβ2MG,CRP and CSF-NSE in mild,moderate,and severe cases,severe children were higher than mild and moderate children,the difference was statistically significant(P<0.05),and moderate children were higher than mild children,the difference was statistically significant(P<0.05).ROC curve analysis showed thatβ2MG,CRP,CSF-NSE and the three combined indicators for the diagnosis of neonatal purulent meningitis in the area under the ROC curve AUC were 0.882,0.840,0.787,0.890,respectively,the three combined AUCs were significantly higher than each single indicator(P<0.05).Conclusion Cerebrospinal fluidβ2MG,CRP and CSF-NSE are significantly inc

关 键 词：脑脊液β2MG、CRP及CSF-NSE 新生儿化脓性脑膜炎 

分 类 号：R722.1[医药卫生—儿科]