HMGB1、EOS、IL-23与慢性鼻窦炎病变范围关系及诊断价值  

Relationship between HMGB1,EOS,IL-23 and the extent of chronic sinusitis and its diagnostic value

作　　者：魏鑫鑫[1] 许欢[1] 闫一敏 尹中普[1] WEI Xinxin;XU Huan;YAN Yimin;YIN Zhongpu(Department of Otolaryngology,Head and Neck Surgery,Nanyang Central Hospital,Nanyang,Henan,China,473000)

机构地区：[1]南阳市中心医院耳鼻咽喉头颈外科一病区,河南南阳473000

出　　处：《分子诊断与治疗杂志》2021年第10期1644-1647,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技发展计划项目(172102310167)。

摘　　要：目的探讨高迁移率族蛋白B1(HMGB1)、嗜酸性粒细胞(EOS)、白介素-23(IL-23)与慢性鼻窦炎(CRS)病变范围关系及诊断价值。方法选取2019年1月至2020年12月南阳市中心医院收治的98例CRS患者(CRS组)及体检中心45例健康人群作为对照组,比较两组基线资料、HMGB1、EOS、IL-23水平,并比较各指标不同表达水平者视觉模拟评分法(VAS)、Lund-Mackay评分,应用Pearson、多因素Logistic回归方程、受试者工作特征曲线(ROC)及ROC下面积(AUC)处理分析数据。结果CRS组CRS家族史、HMGB1、EOS、IL-23与对照组比较,差异有统计学意义(P<0.05);HMGB1、EOS、IL-23高水平者VAS评分、Lund-Mackay评分高于低水平者,差异有统计学意义(P<0.05);HMGB1、EOS、IL-23与VAS评分、Lund-Mackay评分呈正相关(P<0.05);多因素Logistic回归方程分析显示,将CRS家族史控制后,HMGB1、EOS、IL-23仍是CRS的相关危险因素(P<0.05);HMGB1、EOS联合IL-23的AUC为0.951,高于HMGB1的0.818、EOS的0.856、IL-23的0.803。结论CRS患者HMGB1、EOS、IL-23较正常人群升高,与主观病情、病变范围有关,可作为诊断CRS生物标志物,从而为临床诊治提供参考信息。Objective To investigate the relationship between high mobility group protein B1(HMGB1),eosinophils(EOS),interleukin-23(IL-23)and the extent of chronic sinusitis(CRS)and its diagnostic value.Methods A total of 98 CRS patients admitted to Nanyang Central Hospital from January 2019 to December 2020 were selected as the CRS group and 45 healthy people from the physical examination center were selected as the control group.The baseline data,HMGB1,EOS,and IL-23 levels of the two groups were compared.The visual analogue scoring(VAS)and Lund-Mackay scores of people with different expression levels of each indicator were compared.Pearson,multivariate Logistic regression equation,receiver operating characteristic curve(ROC)and area under ROC(AUC)were used to process and analyze the data.Results Compared with the control group,the CRS family history,HMGB1,EOS and IL-23 in the CRS group showed statistically significant differences(P<0.05).The VAS score and Lund-Mackay score of those with high levels of HMGB1,EOS,and IL-23 were higher than those with low Levels(P<0.05).HMGB1,EOS,IL-23 were positively correlated with the VAS score and Lund-Mackay score(P<0.05).Multivariate logistic regression analysis showed that after controlling the family history of CRS,HMGB1,EOS,IL-23 werestill related risk factors for CRS(P<0.05).The AUC of HMGB1 and EOS combined with IL-23 was 0.951,which was higher than 0.818 of HMGB1,0.856 of EOS,and 0.803 of IL-23.Conclusion HMGB1,EOS,and IL-23 in CRS patients are higher than those in the normal population,which are related to the subjective condition and lesion range,and can be used as biomarkers for the diagnosis of CRS,thereby providing reference information for clinical diagnosis and treatment.

关 键 词：HMGB1 EOS IL-23 慢性鼻窦炎 病变范围 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]