HDCP产妇血清APN、chemerin、sFlt-1/PIGF与围产结局的相关性  

Correlation between HDCP maternal serum APN,chemerin,sFlt-1/PIGF and perinatal outcome

作　　者：程锦 周萍 李茗薇 马宁 吴泉 CHENG Jin;ZHOU Ping;LI Mingwei;MA Ning;WU Quan(Department of Obstetrics and Gynecology,the First Affiliated Hospital of Anhui University of Technology,Huainan First People's Hospital,Huainan,Anhui,China,232007)

机构地区：[1]安徽理工大学第一附属医院·淮南市第一人民医院妇产科,安徽淮南232007

出　　处：《分子诊断与治疗杂志》2021年第10期1697-1700,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生厅科研计划项目(2019SEYL013)。

摘　　要：目的探讨妊娠期高血压(HDCP)产妇血清脂联素(APN)、chemerin、可溶性血管内皮生长因子受体-1(sFlt-1)与胎盘生长因子(PIGF)比值与围产结局的相关性。方法选取2019年1月至2021年1月在安徽理工大学第一附属医院分娩的102例HDCP产妇作为研究组,另选取63例同期健康产妇作为对照组,比较两组血清APN、chemerin、sFlt-1/PIGF水平,探讨上述指标在HDCP中的诊断效能,并分析上述指标与围产结局的相关性。结果研究组APN明显低于对照组,Chemerin、sFlt-1/PIGF高于对照组,差异均有统计学意义(P<0.05)。血清APN、Chemerin、sFlt-1/PIGF联合诊断HDCP曲线下面积(AUC)为0.965,明显高于单种指标诊断效能(P<0.05)。多因素Logistic回归分析显示,收缩压(SBP)、舒张压(DBP)、Chemerin、sFlt-1/PIGF是影响HDCP产妇出现不良围产结局的危险因素,APN为保护因素(P<0.05)。结论血清APN、chemerin、sFlt-1/PIGF可作为临床诊断HDCP的有效指标,且上述指标与不良围产结局有密切关系,提示临床需给予针对性早期干预,改善围产结局。Objective To explore the correlation of serum adiponectin(APN),chemerin and soluble vascular endothelial growth factor receptor-1(sFlt-1)to placental growth factor(PIGF)ratio with perinatal outcomes of puerperae with hypertensive disorder complicating pregnancy(HDCP).Methods A total of 102 puerperae with HDCP who delivered in the First Affiliated Hospital of Anhui University of Science and Technology were selected as the study group between January 2019 and January 2021.Meanwhile,63 healthy puerperae were selected as the control group.The levels of serum APN,chemerin and sFlt-1/PIGF were compared between the two groups.The diagnostic efficiencies of the above indicators for HDCP were discussed,and their correlation with perinatal outcomes was analyzed.Results The APN level in the study group was significantly lower than that in the control group,while chemerin and sFlt-1/PIGF were higher than those in the control group(P<0.05).The area under the curve(AUC)of serum APN combined with chemerin and sFlt-1/PIGF in the diagnosis of HDCP was 0.965,which was significantly higher than the diagnosis efficiency of a single indicator(P<0.05).Multivariate Logistic regression analysis showed that systolic blood pressure(SBP),diastolic blood pressure(DBP),chemerin and sFlt-1/PIGF were risk factors for adverse perinatal outcomes in puerperae with HDCP,and APN was a protective factor(P<0.05).Conclusion Serum APN,chemerin,and s Flt-1/PIGF can be used as effective indicators for clinical diagnosis of HDCP,and theabove indicators are closely related to poor perinatal outcomes,suggesting that targeted early intervention is needed to improve perinatal outcomes.

关 键 词：妊娠期高血压 脂联素 CHEMERIN 可溶性血管内皮生长因子受体-1 胎盘生长因子 

分 类 号：R714.246[医药卫生—妇产科学]