肺部颗粒运动机制模型的研究进展  

Research progress of pulmonary particle movement mechanical model

作　　者：许都昌 赖开澄 金义光 徐远清[1] XU Du-chang;LAI Kai-cheng;JIN Yi-guang;XU Yuan-qing(School of Life Science,Beijing Institute of Technology,Beijing 100081,China;Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]北京理工大学生命学院,北京100081 [2]军事科学院军事医学研究院辐射医学研究所,北京100850

出　　处：《药学学报》2021年第10期2622-2629,I0001,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81771935)。

摘　　要：肺吸入颗粒在肺组织内部运动和沉积对人体的呼吸生理有重要影响。其颗粒运动机制和沉积研究模型对于探究肺部疾病的致病因素及治疗方法有重要的应用价值,如评估肺部雾化给药的优化设计及空气颗粒污染物对肺部的影响等。本文根据建模依据的知识和方法不同,对近年来主要的肺部颗粒运动机制模型进行了分类、梳理和分析,将相应机制模型分为生物学模型、物理学模型和数值模拟模型。生物学模型包括体内成像法和药代动力学方法;物理学模型包括实物实体建模法和微流控芯片建模法;数值模型包括呼吸道模型、气流模拟模型及颗粒模拟模型。同时还对相应的数值求解及流固耦合等模型进行综述,其中,重点分析了格子Boltzmann方法的应用前景。The movement and deposition of inhaled particles in the lung tissue have an important influence on the respiratory physiology of human body.The corresponding particle dynamics model plays a vital role in exploring the pathogenic factors and treatment methods of lung diseases.Such as evaluating the optimal design of pulmonary atomization drug delivery and the impact of particulate air pollutants on the lung.According to the different knowledge and modeling methods,this paper classifies,combs and analyzes several representative particle dynamics models in lung airways in recent years.We divided the mechanism models into the biological model,physical model and numerical simulation model.The biological models include in vivo imaging and pharmacokinetic methods;physical models include bionic and microfluidic chip models;the numerical models include respiratory tract model,airflow model and particle model.Moreover,the numerical solution and fluid-structure-interaction models were also reviewed,especially the application prospect of the lattice Boltzmann method.

关 键 词：肺 机制模型 颗粒运动 数值模拟 格子BOLTZMANN方法 

分 类 号：R943[医药卫生—药剂学]