益气除痰方穴位贴敷治疗晚期非小细胞肺癌癌因性疲劳的临床研究  

Clinical Study on Acupoint Application of Yi Qi Chu Tan Formula for Cancer Related Fatigue in Advanced Non-small Cell Lung Cancer

作　　者：陈泽仁 吴融 孙玲玲[3] 廖志晓 周京旭[3] CHEN Ze-ren;WU Rong;SUN Ling-ling;LIAO Zhi-xiao;ZHOU Jing-xu(First School of Clinical Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;Guangdong Second Hospital of Traditional Chinese Medicine,Guangzhou 510095,China;First Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一临床医学院,广州510405 [2]广东省第二中医院,广州510095 [3]广州中医药大学第一附属医院,广州510405

出　　处：《上海针灸杂志》2021年第10期1185-1190,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：广东省自然科学基金项目(2020A1515011176)。

摘　　要：目的观察益气除痰方穴位贴敷治疗晚期非小细胞肺癌(NSCLC)患者癌因性疲劳(CRF)的临床疗效和安全性。方法将64例NSCLC并伴有CRF的患者随机分为试验组和对照组,每组32例。两组均按原定抗肿瘤方案治疗,对照组予常规对症治疗,试验组在对照组治疗基础上予益气除痰方穴位贴敷治疗。治疗前后观察多维疲劳量表(multidimensional fatigue inventory, MFI)、卡氏量表(KPS)评分、血常规指标、血肝肾功能指标和大小便常规指标的变化,比较两组临床疗效和安全性。结果治疗后,两组MFI、KPS评分均较治疗前改善(P<0.05),且试验组优于对照组(P<0.05)。对照组治疗后血红蛋白(HGB)水平较治疗前下降(P<0.05),两组治疗后其他血常规指标、血肝肾功能指标、大小便常规指标较治疗前无明显变化(P>0.05)。试验组总有效率为96.9%,高于对照组的81.3%(P<0.05)。两组均未见不良事件发生。结论益气除痰方穴位贴敷治疗晚期非小细胞肺癌患者癌因性疲劳,可改善疲劳症状,提高生活质量,疗效优于常规对症治疗,且安全性好。Objective To observe the clinical efficacy and safety of acupoint application of Yi Qi Chu Tan formula for cancer related fatigue(CRF) in patients with advanced non-small cell lung cancer(NSCLC). Method Sixty-four NSCLC patients with CRF were randomized to an experimental group and a control group, with 32 cases in each group.Both groups were treated according to the original antitumor protocol. The control group received conventional symptomatic treatment and the experimental group received acupoint application of Yi Qi Chu Tan formula in addition.The multidimensional fatigue inventory(MFI) score and the Karnofsky performance status scale(KPS) score were recorded and routine blood indicators, blood liver and kidney function indicators and routine urine and feces indicators were measured before and after treatment. The clinical efficacies and safeties were compared between the two groups.Result After treatment, the MFI score and the KPS score improved in the two groups compared with before(P<0.05)and were better in the experimental group than in the control group(P<0.05). After treatment, hemoglobin(HGB)levels decrease in the control group compared with before(P<0.05) and other routine blood indicators, blood liver and kidney function indicators and routine urine and feces indicators did not significantly change in the two groups compared with before(P>0.05). The total efficacy rate was 96.9% in the experimental group, which was higher than 81.3% in the control group. No adverse reactions occurred in the two groups. Conclusion Acupoint application of Yi Qi Chu Tan formula can relieve fatigue symptoms and improve the quality of life and is more effective than conventional symptomatic treatment with good safety in treating cancer related fatigue in patients with advanced non-small cell lung cancer.

关 键 词：穴位贴敷法 癌 非小细胞肺 疲劳 多维疲劳量表 卡氏量表 

分 类 号：R246.5[医药卫生—针灸推拿学]