糖尿病患者血清25羟维生素D_(3)表达改变及其与大血管并发症的相关性分析  

Changes of serum 25 hydroxyvitamin D_(3) expression in diabetic patients and its correlation with macrovascular complications

作　　者：王荣荣[1] 赵永才[1] 周亚男[1] 张燕[1] 丁文萃[1] 钱红霞[1] 王男[2] Wang Rongrong;Zhao Yongcai;Zhou Ya′nan;Zhang Yan;Ding Wencui;Qian Hongxia;Wang Nan(Department of Endocrinology and Diabetes,Cangzhou Central Hospital,Hebei Cangzhou 061000,China;Department of Nursing,Cangzhou Central Hospital,Hebei Cangzhou 061000,China)

机构地区：[1]河北省沧州市中心医院内分泌糖尿病科,061000 [2]河北省沧州市中心医院护理部,061000

出　　处：《中国医师进修杂志》2021年第10期913-916,共4页Chinese Journal of Postgraduates of Medicine

基　　金：河北省沧州市重点研发计划(172302158)。

摘　　要：目的分析糖尿病患者血清25羟维生素D_(3)[25-(OH)D_(3)]表达改变及其与大血管并发症的相关性。方法选择河北省沧州市中心医院2018年2月至2019年11月收治的200例糖尿病患者,依据有无大血管并发症分为有大血管并发症组87例及无大血管并发症组113例;依据25-(OH)D_(3)缺乏程度分为25-(OH)D_(3)正常组32例,轻度缺乏组94例,中重度缺乏组74例。同期选择门诊健康体检者168例作为对照组。比较糖尿病组与对照组、有大血管并发症组与无大血管并发症组血清25-(OH)D_(3)水平的差异,并分析合并糖尿病大血管并发症患者血清25-(OH)D_(3)水平与颈动脉内膜中层厚度(IMT)的相关性。结果糖尿病组血清25-(OH)D_(3)水平低于对照组[(24.79±3.02)μg/L比(39.18±4.38)μg/L],差异有统计学意义(t=37.132,P<0.05)。糖尿病有大血管并发症组血清25-(OH)D_(3)水平低于无大血管并发症组[(21.08±2.64)μg/L比(27.65±3.31)μg/L],IMT水平则高于无大血管并发症组[(1.29±0.13)mm比(0.93±0.10)mm],差异有统计学意义(P<0.05)。25-(OH)D_(3)正常组、轻度缺乏组、中重度缺乏组大血管并发症发生率分别为12.50%(4/32)、40.43%(38/94)、60.81%(45/74),差异有统计学意义(χ^(2)=21.896,P<0.05)。糖尿病大血管并发症患者血清25-(OH)D_(3)水平与IMT呈负相关(r=-0.513,P<0.05)。结论糖尿病患者血清25-(OH)D_(3)水平有所下降,其水平变化与糖尿病患者大血管并发症的发生有关。Objective To analyze the changes of serum 25-hydroxyvitamin D_(3)[25-(OH)D_(3)]expression in diabetic patients and its correlation with macrovascular complications.Methods Two hundreddiabetic patients admitted to Cangzhou Central Hospital from February 2018 to November 2019 were divided into macrovascular complications group(87 cases)and without macrovascular complicationsgroup(113 cases).According to the degree of 25-(OH)D_(3) deficiency,32 cases were divided into 25-(OH)D_(3) normal group,94 cases were mild deficiency group and 74 cases were moderate and severe deficiency group.At the same time,168 outpatients were selected as control group.The levels of serum 25-(OH)D_(3) were compared between diabetic group and control group,macrovascular complications group and without macrovascular complications group,and the correlation between the level of serum 25-(OH)D_(3) and carotid intima-media thickness(IMT)was analyzed.Results The level of serum 25-(OH)D_(3) in diabetic group was lower than that in control group:(24.79±3.02)μg/L vs.(39.18±4.38)μg/L,the difference was statistically significant(P<0.05).The level ofserum 25-(OH)D_(3) in diabetic patients with macrovascular complications group was lower than that in without macrovascular complications group:(21.08±2.64)μg/L vs.(27.65±3.31)μg/L;while the IMT was higher than that without macrovascular complications group:(1.29±0.13)mm vs.(0.93±0.10)mm,the differences were statistically significant(P<0.05).The incidence of macrovascular complications in 25-(OH)D_(3) moderate and severe deficiency group was higher than that in 25-(OH)D_(3) mild deficiency group and 25-(OH)D_(3) normal group:60.81%(45/74)vs.40.43%(38/94),12.50%(4/32),the difference was statistically significant(χ^(2)=21.896,P<0.05).The level of serum 25-(OH)D_(3) in patients with diabetic macrovascular complications was negatively correlated with IMT(r=-0.513,P<0.05).Conclusions The level of serum 25-(OH)D_(3) in diabetic patients is decreased,and the change of its concentration is related to the

关 键 词：糖尿病血管病变 25羟维生素D_(3) 相关性 

分 类 号：R587.2[医药卫生—内分泌]