低背景信号的高级生物分析方法:光电化学生物分析  

Advanced Bioanalysis Methods with Low Background Signal: Photoelectrochemical Bioanalysis

作　　者：方凯 姜磊[1] 杨丽敏[1] Fang Kai;Jiang Lei;Yang Limin(State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology,China University of Petroleum(East China),Qingdao,266580)

机构地区：[1]中国石油大学(华东)重质油国家重点实验室及生物工程与技术中心,青岛266580

出　　处：《化学通报》2021年第10期1031-1039,共9页Chemistry

基　　金：国家自然科学基金项目(31871878)资助。

摘　　要：光电化学传感是近年来兴起并发展迅速的一种生物分析技术,其检测的主要原理是生物识别原件识别靶标物质而引起光电活性材料的光电性能变化,最终导致光电流值发生变化,从而达到检测的目的。由于光电化学生物分析中输入信号是光,输出信号是电,这赋予了此种检测方法背景信号低、灵敏度高的天然优势,这种优势所展现出来的潜力使光电化学分析在检测领域受到了越来越多的关注。本文介绍了光电化学生物传感的基本原理、光电活性材料的分类以及光电化学生物传感的传感模式,最后对其未来的发展进行了展望。Photoelectrochemical sensing is a biological analysis technology that has emerged and developed rapidly in recent years. The main principle of its detection is that the biological recognition component interacts with the target substance, which causes the change in the photoelectric performance of the photoelectrically active material, resulting in a change in the photocurrent value, and finally achieves the purpose of detection. In photoelectrochemical bioanalysis, the input signal is light and the output signal is electricity. This gives this detection method the natural advantages of low background signal and high sensitivity. The potential demonstrated by this advantage has made photoelectrochemical analysis attract more and more attention in the field of detection. In this article, the basic principles of photoelectrochemical biosensing, the classification of photoelectric active materials and the sensing mode of photoelectrochemical biosensing are introduced, and its future development trend is prospected.

关 键 词：光电化学传感 生物分析 光电活性材料 传感模式 

分 类 号：Q503[生物学—生物化学] TP212.9[自动化与计算机技术—检测技术与自动化装置]