芳烃酰基化后还原制备芳香醇的工艺进展  

Research Progress in the Syntheses of Aromatic Alcohols by the Reduction of Aromatic Acylation Products

作　　者：李辰鑫 霍琳梦 王甜 蒲彦锋 乔聪震[1] 柏 Li Chenxin;Huo Linmeng;Wang Tian;Pu Yanfeng;Qiao Congzheng;Bai Yan(College of Chemistry and Chemical Engineering,Henan University,Henan Province Engineering Research Center of Catalytic Reaction,Kaifeng,475004)

机构地区：[1]河南大学化学化工学院河南省催化反应工程研究中心,开封475004

出　　处：《化学通报》2021年第10期1048-1053,1059,共7页Chemistry

基　　金：国家科技支撑计划项目(2013BAB11B02);河南省科技攻关项目(212102210210)资助。

摘　　要：芳烃制备高附加值精细化学品芳香醇(9-芴甲醇),一直以来存在产物选择性低以及合成成本高等问题。基于此,本文主要综述了芳烃酰基化后还原合成芳香醇的工艺,包括第一步采用Friedel-Crafts酰基化反应、Vilsmeier-Haack反应、Reimer-Tiemann反应、Duff反应等过程将芳烃酰基化合成芳香醛/酮;第二步通过金属氢化物还原、催化加氢还原、活泼金属还原、Cannizarro反应、Meerwein-Ponndorf-Verley还原反应等过程将芳香醛/酮还原合成芳香醇。在总结和归纳各种工艺过程优缺点的基础上,提出了合理的芳香醇制备工艺,为9-芴甲醇产业化制备技术的开发提供帮助。There have always been problems about producing high value-added fine chemicals, aromatic alcohols(9-fluorenemethanol) from aromatic hydrocarbons, such as low product selectivity and high-cost synthesis. Based on this background, the syntheses of aromatic alcohols by reduction after acylation of aromatic hydrocarbon were reviewed in this paper, including the first step of syntheses of aromatic aldehydes/ketones from aromatic hydrocarbons by Friedel-Crafts acylation, Vilsmeier-Haack reaction, Reimer-Tiemann reaction, Duff reaction and so on. In a second step, aromatic aldehydes/ketones were reduced to the corresponding aromatic alcohols using metal hydride reduction, catalytic hydrogenation reduction, active metal reduction, Cannizarro reaction and Meerwein-Ponndorf-Verley reduction reaction. Finally, by reviewing the advantages and disadvantages of various technological processes, a reasonable technological process for aromatic alcohols was proposed, which provides help for the development of the industrial production technology of 9-fluorene methanol.

关 键 词：芳香醇 芳香醛 芴甲醇 酰基化 还原反应 

分 类 号：TQ243.4[化学工程—有机化工]