磁敏感加权成像预测原发性中枢神经系统淋巴瘤化疗反应性和无进展生存期初探  

Preliminary Study on the Prediction of Chemotherapy Responsiveness and Progression-Free Survival by SWI in Primary Central Nervous System Lymphoma

作　　者：张禹 朱友志[2] 刘斌[1] 骆祥伟[2] 张茜[2] ZHANG Yu;ZHU Youzhi;LIU Bin;LUO Xiangwei;ZHANG Qian(Department of Radiology,The First Affiliated Hospital,Anhui Medical University;Department of Radiology,The No.901 Hospital of the Joint Logistics Support Force of PLA)

机构地区：[1]安徽医科大学第一附属医院放射科 [2]中国人民解放军联勤保障部队第901医院放射科

出　　处：《中国医学计算机成像杂志》2021年第5期393-397,共5页Chinese Computed Medical Imaging

基　　金：安徽省重点研究和开发计划(1804h08020284)。

摘　　要：目的:分析磁敏感加权成像(SWI)对原发性中枢神经系统淋巴瘤(PCNSL)化疗反应性和无进展生存期(PFS)的预测价值。方法:纳入15例PCNSL,化疗前均行SWI扫描,评估肿瘤磁敏感信号(ITSS),根据PFS中位值、4周期化疗后初始疗效(完全缓解和部分缓解)分别进行分组,再根据年龄中位值、瘤灶数量(单发和多发)、有无ITSS、高低ADC值进行分组,建四格表,采用Fisher精确概率法分析各指标分组间差异。结果:PFS3~30个月,中位值为13个月;初始疗效为完全缓解(CR)及部分缓解(PR),分别为9例和6例。不同年龄(P=0.001)、有无ITSS(P=0.001)、高低ADC值(P=0.041)、初始疗效(P=0.007)之间的PFS高(>13个月)、低(≤13个月)差异有统计学意义,不同年龄(P=0.001)、PFS(P=0.007)、高低ADC值(P=0.035)、有无ITSS(P=0.028)之间的初始疗效(CR和PR)差异有统计学意义。结论:SWI或可预测PCNSL化疗反应性和PFS。Purpose:To analyze the predictive value of susceptibility weighted imaging(SWI)in chemotherapy responsiveness and progression-free survival(PFS)of primary central nervous system lymphoma(PCNSL).Methods:Fifteen cases of PCNSL confirmed by clinical and pathological diagnosis were collected.MRI plain and enhanced scan and SWI scanning sequence were implemented before chemotherapy,and then the intratumoral susceptibility signal intensity(ITSS)were evaluated.According to the median value of PFS,initial curative effect after four cycles of chemotherapy(complete response[CR]and partial response[PR]),all the cases were divided into two groups;and then,according to the median age,the number of tumor(single and multiple),the average value of ADC(high and low ADC),ITSS(present and absence),PFS median(high and low PFS),initial curative effect(CR and PR),all the cases were divided into two groups,respectively;finally,the fourfold table was built.By Fisher’s exact probability test,the differences in PFS and initial efficacy between the two groups of each indicator were analyzed,respectively.Results:The age range was 46-79 years old and median value was 60 years old,10 males and5 females,PFS range was 3-30 months and median value was 13 months.Nine cases obtained CR,6 cases obtained PR,9 cases showed with ITSS.There were statistical significant differences in age(P=0.001),ADC(P=0.041),ITSS(P=0.001)and initial efficacy(P=0.007)between the two groups with high and low PFS.There were statistical significant differences in age(P=0.001),PFS(P=0.007),ADC(P=0.035)and ITSS(P=0.028)between the two groups with different initial efficacy(CR and PR).Conclusion:SWI may be used to predict the chemotherapeutic responsiveness and PFS of PCNSL.

关 键 词：中枢神经系统 淋巴瘤 磁共振成像 磁敏感加权成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]