颧部褐青色斑激光治疗后炎症性色素沉着的危险因素分析  

Risk factors of postinflammatory hyperpigmentation after laser in treatment of acquired bilateral nevus of Ota-like macules

作　　者：马少吟[1] 龚业青[1] 张文君[1] 李佩斯 李月明 何诗琪 王博仪 朱慧兰[1] Ma Shaoyin;Gong Yeqing;Zhang Wenjun;Li Peisi;Li Yueming;He Shiqi;Wang Boyi;Zhu Huilan(Department of Laser and Physiotherapy,Guangzhou Institute of Dermatology,Guangzhou 510095,China)

机构地区：[1]广州市皮肤病防治所皮肤激光理疗科,510095

出　　处：《中华医学美学美容杂志》2021年第5期424-427,共4页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：广州市卫生健康委科技一般引导项目(20211A011066)。

摘　　要：目的探讨颧部褐青色斑激光治疗后炎症性色素沉着的相关危险因素。方法2011年1月至2018年12月,广州市皮肤病防治所皮肤激光理疗科收治颧部褐青色斑患者120例,男3例、女117例,年龄20~60(32.97±9.17)岁。用1064 nm调Q-Nd∶YAG激光治疗。分析患者不同年龄组、性别、临床分型、皮肤的Fitzpatrick分型、颧部褐青色斑(ABNOM)合并黄褐斑与治疗后出现炎症性色素沉着(PIH)是否存在差异,用非条件logistic回归分析颧部褐青色斑激光术后炎症性色素沉着的危险因素。结果53例(44.17%)颧部褐青色斑患者激光术后出现炎症性色素沉着。单因素分析显示不同年龄组、临床分型、皮肤Fitzpatrick分型和颧部褐青色斑合并黄褐斑出现炎症性色素沉着的概率有统计学意义(P<0.01)。非条件logistic回归分析显示,年龄越大、临床分型越重、颧部褐青色斑合并黄褐斑是颧部褐青色斑术后出现炎症性色素沉着的危险因素。结论颧部褐青色斑需尽早进行激光治疗,年龄越大、临床分型越重、ABNOM合并黄褐斑患者术后诱发炎症性色素沉着的风险越高。Objective To analyze the risk factors of postinflammatory hyperpigmentation(PIH)after laser in the treatment of acquired bilateral nevus of Ota-like macules(ABNOM).Methods A retrospective study was conducted to follow up 120 patients with acquired bilateral nevus of Ota-like macules in the Department of Laser and Physiotherapy,Guangzhou Institute of Dermatology between January 2011 and December 2018,which accepted 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser treatment.The difference was analyzed between different age,sex,clinical classification,Fitzpatrick skin classification,ABNOM with melasma and postinflammatory pigmentation after laser treatment.Logistic regression was used to analyze the risk factors of postinflammatory hyperpigmentation after 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser treatment of acquired bilateral nevus of Ota-like macules.Results Fifty-three ABNOM patients(44.17%)developed PIH after laser treatment.Univariate analysis showed that age,clinical classification,Fitzpatrick skin classification and the patients with both ABNOM and melasma all affected the occurrence of PIH after laser in the treatment of ABNOM,and the difference was statistically significant(P<0.01).Logistic regression showed that older age,more severe clinical classification and the presence of ABNOM with melasma were the risk factors of PIH after treatment of ABNOM.Conclusions ABNOM patients should be treated as early as possible.The risk of inducing PIH is great after laser treatment in patients with more severe clinical classification and patients with both ABNOM and melasma.

关 键 词：面部皮肤病 激光 颧部褐青色斑 炎症性色素沉着 危险因素 

分 类 号：R751[医药卫生—皮肤病学与性病学]