CS/CMC/HAP/TCP复合PGMA材料的合成研究  

Synthesis and Study of Chitosan/Sodium Carboxymethyl Cellulose/Hydroxyapatite/Tricalcium Phosphate Composite PGMA Materials

作　　者：张鹏 黄俊潮 屈亮 张光学 ZHANG Peng;HUANG Jun-chao;ZHANG Guang-xue(School of Nuclear Technology and Chemistry&Biology,Hubei University of Science and Technology,Xianning Hubei 437100,China)

机构地区：[1]湖北科技学院核技术与化学生物学院,湖北咸宁437100

出　　处：《湖北科技学院学报（医学版）》2021年第5期412-415,F0003,共5页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北省大学生创新训练项目(201810921047)。

摘　　要：目的利用天然高分子聚合物壳聚糖(CS)及羧甲基纤维素钠(CMC)与骨组织主要成分羟基磷灰石(HAP)、磷酸三钙(β-TCP)复合聚甲基丙烯酸缩水甘油酯(PGMA),制备一种可临床应用的骨移植材料。方法分别配制20%CS与20%CMC凝胶,将不同质量(HAP/TCP=1)粉体与配制的凝胶充分搅拌混匀,置于模具中定型,在真空干燥后,加甲基丙烯酸缩水甘油酯(GMA),60Coγ射线辐照,并进行力学性能测试和细胞增殖试验。结果经力学试验测定,复合材料压缩强度为317.6MPa;复合材料采用人骨肉瘤细胞进行增值实验,其表面的细胞增值率为9。结论复合材料具有良好的力学性能与较好的生物相容性,完全可作为临床应用的骨移植材料。Objective A kind of clinical bone graft material was prepared by using chitosan(CS),sodium carboxymethyl cellulose(CMC),hydroxyapatite(HAP)and tricalcium phosphate(β-TCP)combined with polyglycidyl methacrylate(PGMA).Methods 20%CS and 20%CMC gels were prepared,and powders of different mass(HAP/TCP=1)were fully stirred and mixed with the prepared gels,and then the gels were set in a mold.After vacuum drying,the glycidyl methacrylate(GMA)was added and was irradiated by 60Coγ-rays.Results The maximum compressive strength of the composite was 317.6MPa by mechanical test.After one week of osteocyte proliferation experiment,the proliferation rate of osteocytes on the surface of the composite material reached 9.Conclusion The composite material has good mechanical properties and good biocompatibility,and could be used as bone graft material for clinical application.

关 键 词：壳聚糖 羧甲基纤维素钠 羟基磷灰石 Β-磷酸三钙 甲基丙烯酸缩水甘油酯 细胞相容性 

分 类 号：TB33[一般工业技术—材料科学与工程]