健脾除湿止带方联合干扰素治疗脾虚湿热型宫颈高危型人乳头瘤病毒感染临床观察  

Clinical observation of Jianpi Chushi Zhidai Formula combined with interferon for cervical high-risk human papillomavirus infection of spleen deficiency damp-heat

作　　者：徐慧婷 谢正华 张甜甜 骆春(指导) XU Huiting;XIE Zhenghua;ZHANG Tiantian(Department of Gynecology,Fangta Hospital of Traditional Chinese Medicine,Shanghai 201699)

机构地区：[1]上海市松江区方塔中医医院妇科,上海201699 [2]不详

出　　处：《河北中医》2021年第7期1132-1135,共4页Hebei Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局全国中医临床特色技术传承骨干人才培训项目(国中医药办人教函〔2019〕36号);上海市松江区科学技术攻关项目(编号:19SJKJGG68)。

摘　　要：目的观察健脾除湿止带方联合干扰素治疗脾虚湿热型宫颈高危型人乳头瘤病毒(HPV)感染的临床疗效。方法将80例宫颈高危型HPV感染脾虚湿热型患者按照随机数字表法分为2组,对照组40例予重组人干扰素α2b阴道泡腾胶囊治疗,治疗组40例在对照组治疗基础上加健脾除湿止带方治疗,均治疗3个月经周期。比较2组临床疗效、治疗前、治疗结束后3个月中医证候评分、随访6个月HPV转阴情况。结果治疗组总有效率95.0%(38/40),对照组85.0%(24/40),治疗组高于对照组(P<0.05)。治疗后2组患者中医证候各项评分均较本组治疗前降低(P<0.05),且治疗组均低于对照组(P<0.05)。治疗组HPV转阴率82.5%(33/40),对照组62.5%(25/40),治疗组高于对照组(P<0.05)。结论健脾除湿止带方联合干扰素治疗脾虚湿热型宫颈高危型HPV感染比单用干扰素治疗可以进一步提高临床疗效,改善患者临床症状,提高HPV转阴率。Objective To observe the clinical efficacy of Jianpi Chushi Zhidai Formula combined with interferon for cervical high-risk human papillomavirus(hr-HPV)infection of spleen deficiency damp-heat.Methods Totally 80 patients with cervical hr-HPV infection(spleen deficiency damp-heat)were randomly divided into 2 groups,40 cases in control group were treated with recombinant human interferonα2b vaginal effervescent capsules,and 40 cases in treatment group with Jianpi Chushi Zhidai Formula on the basis of control group,additionally.Treated for 3 menstrual cycles,the key observation was clinical efficacy,TCM syndrome scoreat pre-treatment and 3-month post-treatment,and negative conversion rate of HPVat 6-month follow-up.Results The effective rate of TCM curative effect in treatment group and control group was 95.0%(38/40)and 85.0%(24/40),respectively,the curative effect being better in treatment group than control group(P<0.05).After treatment,TCM symptom scores in groups were decreased(P<0.05),which decreased notably in treatment group when compared with control group(P<0.05).The negative conversion rate of HPV in treatment group were better than those in control group[82.5%(33/40)vs 62.5%(25/40),(P<0.05),respectively].Conclusion For patients with cervical hr-HPV infection(spleen deficiency damp-heat),the combination of the above two has better clinical efficacy comparedwith interferon alone,which can improve clinical symptoms,and increase negative conversion rate of HPV.

关 键 词：人乳头瘤病毒 宫颈 中西医结合疗法 

分 类 号：R711.740.58[医药卫生—妇产科学]