丹红注射液联合针刺治疗急性呼吸窘迫综合征疗效及对血气指标和炎症因子的影响  

Efficacy of Danhong injection combined with acupuncture on acute respiratory distress syndrome and its effect on blood gas indexes and inflammatory factors

作　　者：杨浩 刘源 王倩飞 王大力 张芷毓 董旭[1] YANG Hao;LIU Yuan;WANG Qianfei;WANG Dali;ZHANG Zhiyu;DONG Xu(The first Affiliated Hospital of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050011,Hebei,China)

机构地区：[1]河北中医学院第一附属医院,河北石家庄050011

出　　处：《现代中西医结合杂志》2021年第31期3431-3435,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2019022,2019042)。

摘　　要：目的观察丹红注射液联合针刺对急性呼吸窘迫综合征患者呼吸功能、血气指标以及炎症因子的影响。方法将2019年3月—2020年10月河北省中医院重症医学科收治的72例急性呼吸窘迫综合征患者按照随机数字表法分为对照组和观察组各36例。对照组给予重症医学科常规治疗,观察组在此基础上给予丹红注射液静点和针刺治疗,2组均治疗2周。比较2组患者机械通气时间、ICU治疗时间,观察2组治疗前后APACHEⅡ评分、序贯性器官功能衰竭评分(SOFA评分),动脉血pH值、氧分压[p(O_(2))]、二氧化碳分压[p(CO_(2))]、血氧饱和度[S a(O_(2))],白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、降钙素原(PCT)水平的变化,统计2组疗效及不良反应发生情况。结果观察组患者机械通气时间、ICU治疗时间明显短于对照组(P均<0.05);2组患者治疗后APACHEⅡ评分、SOFA评分、p(CO_(2))及IL-6、TNF-α、CRP、PCT水平均明显低于治疗前,且观察组上述指标均明显低于对照组,差异均有统计学意义(P均<0.05);治疗后2组患者pH值、p(O_(2))、S a(O_(2))均明显高于治疗前,且观察组上述指标均明显高于对照组,差异均有统计学意义(P均<0.05)。治疗后,观察组总有效率为80.6%(29/36),对照组总有效率为61.1%(22/36),观察组总有效率明显高于对照组(P<0.05)。治疗后2组患者无明显严重不良反应发生。结论丹红注射液联合针刺疗法治疗急性呼吸窘迫综合征临床疗效显著,能明显改善患者呼吸情况和血气分析指标,并减轻炎症反应。Objective It is to observe the effect of Danhong injection combined with acupuncture on respiratory function,blood gas indexes and inflammatory factors in patients with acute respiratory distress syndrome(ARDS).Methods Seventy-two patients with ARDS treated in the Department of Critical Medicine,Hebei Provincial Hospital of Traditional Chinese Medicine from March 2019 to October were randomly divided into control group(n=36)and observation group(n=36).The control group was given routine treatment of the department of critical medicine,the observation group was treated with Danhong injection and acupuncture therapy on the basis of treatment in the control group.Both groups were treated for 4 weeks.The mechanical ventilation time and ICU treatment time of the two groups were compared.The changes in APACHEⅡscore,sequential organ failure score(SOFA score),arterial blood pH value,oxygen partial pressure[p(O_(2))],carbon dioxide partial pressure[p(CO_(2))],blood oxygen saturation[Sa(O_(2))],the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),procalcitonin(PCT)before and after treatment were observed in the two groups,the curative effects and adverse reactions occurred were counted in the two groups.Results The mechanical ventilation time and ICU treatment time of the observation group were significantly shorter than those of the control group(both P<0.05);the APACHEⅡscore,SOFA score,p(CO_(2))and the levels of IL-6,TNF-α,CRP,PCT after treatment were significantly lower than those before treatment in the two groups,and the above indicators of the observation group were significantly lower than those of the control group,the differences were all statistically significant(all P<0.05);the pH,p(O_(2))and S a(O_(2))after treatment were all significantly higher than those before treatment in the two groups,and the above-mentioned indicators of the observation group were significantly higher than those of the control group,the differences were all statistically significant(all P<0.05)

关 键 词：丹红注射液 针刺 急性呼吸窘迫综合征 血气分析 炎症因子 

分 类 号：R563.8[医药卫生—呼吸系统]